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Original research
Outcome of patients with large vessel occlusion stroke after first admission in telestroke spoke versus comprehensive stroke center
  1. Anne-Laure Kaminsky1,
  2. Gioia Mione1,
  3. Yacoubou Omorou2,
  4. Lisa Humbertjean1,
  5. Mathieu Bonnerot1,
  6. Jean Christophe Lacour1,
  7. Nolwenn Riou-Comte1,
  8. Mohammad Anadani3,4,
  9. Benjamin Gory5,
  10. Sébastien Richard1,6
  1. 1 Department of Neurology, Stroke Unit, University Hospital of Nancy, Nancy, France
  2. 2 Centre d’Investigation Clinique-CIC 1433 Epidémiologie Clinique, CHU Nancy, Nancy, Lorraine, France
  3. 3 Washington University School of Medicine in St Louis, St Louis, Missouri, USA
  4. 4 Neurology, Medical University of South Carolina-College of Medicine, Charleston, South Carolina, USA
  5. 5 Department of Diagnostic and Therapeutic Neuroradiology, University Hospital of Nancy INSERM U1254, Nancy, France
  6. 6 Centre d'Investigation Clinique plurithématique CIC 1433, CHRU, Nancy, Lorraine, France
  1. Correspondence to Dr Anne-Laure Kaminsky, service de neurologie, CHU Nancy, Nancy 54000, France; al.kaminsky{at}chru-nancy.fr

Abstract

Introduction While telestroke allows early intravenous thrombolysis (IVT) for ischemic strokes in spoke centers, mechanical thrombectomy (MT) for large vessel occlusion (LVO) is mainly performed at comprehensive stroke centers (CSCs). We aimed to compare 3 month outcome in patients with LVO after admission to a spoke center using telestroke compared with first CSC admission in our large regional stroke network, irrespective of final treatment decision.

Methods All consecutive LVO patients who were admitted to one of six spoke centers or to the regional CSC within 6 hours of symptom onset were prospectively included from September 1, 2015 to August 31, 2017. All patients admitted to spoke centers were assessed on site with cerebral and vessel imaging. Primary outcome was 3 month favorable outcome (modified Rankin Scale score of 0–2).

Results Distances between spoke centers and CSC ranged from 36 to 77 miles. Among 207 included patients, 132 (63.8%) were first admitted to CSCs and 75 (36.2%) to spoke centers. IVT was administered more in spoke centers (81.3% vs 53.8%, p<0.0001) while MT was performed less (26.7% vs 49.2%, p=0.001) and with a longer time from onset (303 vs 200 min, p<0.0001). No difference was found in 3 month favorable outcome between spoke centers compared with CSCs (32.0% and 35.1%, respectively; OR=0.68; 95% CI 0.42 to 1.10; p=0.12).

Conclusions Despite different distribution of reperfusion therapies for LVO patients managed by telemedicine, we could not demonstrate a difference in functional outcome according to admission location in a large area with long distances between centers.

  • stroke
  • thrombectomy
  • thrombolysis
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Footnotes

  • Contributors A-LK, GM, and SR participated in the design of the study. A-LK, GM, and MB extracted individual patient data and YO performed the statistical analysis. A-LK wrote the first version of the manuscript. All authors contributed to data interpretation and critical revision of the article and approved the final version. All authors gave final approval to submit for publication. GM and SR supervised the project.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial, or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval All patients gave consent to be evaluated with our telestroke network. The data collection for this study were approved by the French National Commission for Data Protection and Liberties CNIL approval: 1892594 v1.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

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