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Intra-arterial chemotherapy for retinoblastoma: transradial and transfemoral approach
  1. Ahmad Sweid,
  2. Pascal Jabbour
  1. Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
  1. Correspondence to Dr Pascal Jabbour, Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA; pascal.jabbour{at}


Intraarterial chemotherapy (IAC) for retinoblastoma has notably changed the natural history of the disease and stands as an encouraging example of selective drug delivery. Targeted drug delivery allows achieving a high drug concentration within target tissue along with low systemic concentration. This maintains a high safety profile along with a high efficacy rate (97%).1–4 Increasing experience, refinements of the technique, and positive results of IAC over the past decade have expanded the indications to deliver treatment to a larger population. The most recent improvement introduced in our practice was administering the therapy using the transradial approach. Herein, we demonstrate the technique for IAC using both the transradial and transfemoral approach (video 1).

  • intervention
  • neoplasm
  • pediatrics
  • technique

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  • Twitter @PascalJabbourMD

  • Contributors Both authors prepared the video.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial, or not-for-profit sectors.

  • Competing interests PJ is a consultant for Medtronic and MicroVention.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.