Footnotes

• Twitter @GaborTothMD, @JoshuaAHirsch

• Contributors All authors contributed to the writing of this manuscript.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Patient consent for publication Not required.

• Provenance and peer review Commissioned; internally peer reviewed.