Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data

Johannes Kaesmacher; Thomas Raphael Meinel; Christoph Kurmann; Osama O Zaidat; Alicia C Castonguay; Syed F Zaidi; Nils Mueller-Kronast; Manon Kappelhof; Diederik W J Dippel; Marc Soudant; Serge Bracard; Michael D Hill; Mayank Goyal; Daniel Strbian; Daniel M Heiferman; William Ashley; Mohammad Anadani; Alejandro M Spiotta; Tomas Dobrocky; Eike I Piechowiak; Marcel Arnold; Martina Goeldlin; David Seiffge; Pascal J Mosimann; Pasquale Mordasini; Jan Gralla; Urs Fischer

doi:10.1136/neurintsurg-2020-016680

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Ischemic stroke

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Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data

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Johannes Kaesmacher University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland University Institute of Diagnostic, Interventional and Pediatric Radiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles
Thomas Raphael Meinel Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles
Christoph Kurmann University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles
Osama O Zaidat Neuroscience, St Vincent Mercy Hospital, Toledo, Ohio, USA PubMed articles Google scholar articles
Alicia C Castonguay Neurology, University of Toledo Health Science Campus, Toledo, Ohio, USA PubMed articles Google scholar articles
Syed F Zaidi Neurology, University of Toledo Health Science Campus, Toledo, Ohio, USA PubMed articles Google scholar articles
Nils Mueller-Kronast Neurology, St. Mary's Medical Center, Delray Medical Center, Boynton Beach, Florida, USA PubMed articles Google scholar articles
Manon Kappelhof Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands PubMed articles Google scholar articles
Diederik W J Dippel Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands PubMed articles Google scholar articles
Marc Soudant Clinical Investigation Centre-Clinical Epidemiology 1433, INSERM, University Hospital Centre Nancy, Université de Lorraine, Nancy, France PubMed articles Google scholar articles
Serge Bracard Neuroradiology, CHRU-Nancy, University de Lorraine, Nancy, France PubMed articles Google scholar articles
Michael D Hill Clinical Neurosciences, University Of Calgary, Calgary, Alberta, Canada PubMed articles Google scholar articles
Mayank Goyal Diagnostic Imaging, University of Calgary, Calgary, Alberta, Canada PubMed articles Google scholar articles
Daniel Strbian Neurology, University of Helsinki, Helsinki, Finland PubMed articles Google scholar articles
Daniel M Heiferman Neuroradiology, Semmes Murphey Clinic, Memphis, Tennessee, USA PubMed articles Google scholar articles
William Ashley Neurosurgery, The Sandra and Malcolm Berman Brain and Spine Institute, Sinai Hospital and LifeBridge Health System, Baltimore, Maryland, USA PubMed articles Google scholar articles
Mohammad Anadani Neurology, Washington University School of Medicine, Saint Louis, Missouri, USA Neurology, Medical University of South Carolina - College of Medicine, Charleston, South Carolina, USA PubMed articles Google scholar articles
Alejandro M Spiotta Neurology, Medical University of South Carolina - College of Medicine, Charleston, South Carolina, USA PubMed articles Google scholar articles
Tomas Dobrocky University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles
Eike I Piechowiak University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles
Marcel Arnold Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles
Martina Goeldlin Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles
David Seiffge Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles
Pascal J Mosimann University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland Neuroradiology, Alfried Krupp Krankenhaus, Essen, Germany PubMed articles Google scholar articles
Pasquale Mordasini University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles
Jan Gralla University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles
Urs Fischer Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland PubMed articles Google scholar articles

Correspondence to Johannes Kaesmacher, Neuroradiology, Inselspital Universitatsspital Bern, 3001 Bern, Switzerland; johannes.kaesmacher{at}insel.ch

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Kaesmacher J, Meinel TR, Kurmann C, et al

Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data

Journal of NeuroInterventional Surgery 2021;13:1073-1080.

Publication history

Received July 28, 2020
Revised November 17, 2020
Accepted December 1, 2020
First published January 29, 2021.

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January 07, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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