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Quality of life among ischemic stroke patients eligible for endovascular treatment: analysis of the DEFUSE 3 trial
  1. Ganesh Asaithambi1,
  2. Megan E Tipps2
  1. 1 Neurosciences, Allina Health United Hospital, St. Paul, Minnesota, USA
  2. 2 Neuroscience Research, Allina Health, Minneapolis, Minnesota, USA
  1. Correspondence to Dr Ganesh Asaithambi, Neurosciences, Allina Health United Hospital, St. Paul, MI 55102, USA; ganesh785{at}gmail.com

Abstract

Background The endovascular treatment (ET) for acute ischemic stroke is increasing among eligible patients. Assessing patients’ perspectives on quality of life (QOL) can supplement the use of formal outcome scales and enable the assessment of outcomes across multiple domains affected by stroke.

Methods We analyzed publicly available data from the Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke (DEFUSE 3) trial. We evaluated patients who survived beyond the time of discharge from their acute hospitalizations and completed all Neuro-QOL short forms at 90-day follow-up.

Results Our final analysis included 128 patients (median age 67 [range 23–90] years, 50.8% men). As modified Rankin Scale (mRS) scores increased, there was a consistent increase in the severity of Neuro-QOL measures. T-scores for mobility, cognitive function, and the ability to participate in social roles declined significantly while depression T-scores increased significantly. We found that QOL T-scores for patients with mRS 3 did not differ significantly from T-scores for patients with mRS 2 in any domain.

Conclusions Among ischemic stroke patients eligible for ET, QOL scores help validate and supplement quantitatively measured outcomes.

  • stroke
  • thrombectomy
  • intervention
  • statistics

Data availability statement

Data are available in a public, open access repository.

Statistics from Altmetric.com

Data availability statement

Data are available in a public, open access repository.

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Footnotes

  • Contributors Each author listed should receive authorship credit based on substantial contribution to this article, revision of this article, and final approval of this article for submission to this journal.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial, or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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