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Treatment of wide-necked bifurcation aneurysms with the eCLIPs device: 5-year experience of a single center
  1. Jose Danilo Bengzon Diestro1,
  2. Michael B Keough2,
  3. Robert A Ashforth3,
  4. Michael M Chow2,
  5. Jeremy L Rempel3,
  6. Thomas R Marotta1,
  7. Cian O'Kelly2
  1. 1 Division of Diagnostic and Therapeutic Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
  2. 2 Division of Neurosurgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
  3. 3 Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada
  1. Correspondence to Dr Jose Danilo Bengzon Diestro, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; danni.diestro{at}


Background The endovascular clip system (eCLIPs) is a novel device with both neck bridging and flow-diversion properties that make it suitable for the treatment of wide-necked bifurcation aneurysms.

Objective To describe the clinical and radiologic outcomes of the eCLIPs device, including the first-in-man use of the latest version of the device.

Methods This is a retrospective case series on all the wide-necked bifurcation aneurysms treated with the eCLIPs device in our center. The immediate and latest radiologic and clinical outcomes were assessed.

Results The device was successfully implanted in 12 of 13 patients. After a median follow-up period of 19 months (range 3–64 months), all patients with available data (11/12) had a good radiologic outcome (modified Raymond-Roy classification scores of 1 or 2). Two patients (18.2%) underwent re-treatment with simple coiling through the device. One of these had a subarachnoid hemorrhage prior to re-treatment. There were no major complications (death or permanent neurologic deficits) associated with use of the device.

Conclusion Our series demonstrates occlusion rates that are similar to those of standard stent-assisted coiling and intrasaccular flow diversion for wide-necked bifurcation aneurysms. Larger registry-based studies are necessary to support our findings.

  • device
  • aneurysm

Data availability statement

Data are available upon reasonable request.

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Data availability statement

Data are available upon reasonable request.

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  • Contributors JDBD and MBK are primary investigators. They made substantial contributions to the conception or design of the work, acquisition of data, drafting of the work, and approval of the final version. RAA, MMC, JLR, TRM, and CO’K are supervising investigators. They all made substantial contributions to the conception and design of the work, data interpretation, revision of the manuscript for important intellectual content, and approval of the final version. All the authors agree to be held accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. CO'K is the guarantor for this study.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests TRM is a principal of eVasc Neurovascular, manufacturers of the eCLIPs. JDBD is currently on the editorial board of JNIS as a fellow of the JNIS.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.