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SNIS 20th annual meeting electronic poster abstracts
E-184 Morphological characteristics of brain aneurysms among age groups
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  1. S Sanchez1,
  2. M Essibayi2,
  3. M Hickerson1,
  4. D Ojeda1,
  5. S Al Kasab2,
  6. S Yoshimura3,
  7. P Jabbour4,
  8. J Mascitelli5,
  9. M Levitt6,
  10. H Cuellar-Saenz7,
  11. W Brinjikji8,
  12. A Spiotta9,
  13. A Shaban1,
  14. E Samaniego1
  1. 1Neurology, University of Iowa, Iowa City, IA, USA
  2. 2Neurology, Medical University of South Carolina, Charleston, SC, USA
  3. 3Neurosurgery, Hyogo College of Medicine, Nishinomiya Hyōgo, Japan
  4. 4Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA
  5. 5Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
  6. 6Neurosurgery, University of Washington, Seattle, WA, USA
  7. 7Neurosurgery, LSU Health Shreveport, Shreveport, LA, USA
  8. 8Radiology, Mayo Clinic, Rochester, MN, USA
  9. 9Neurosurgery, Medical University of South Carolina, Charleston, SC, USA

Abstract

Background Age is a risk determinant in various clinical scales. Current knowledge about the morphology of ruptured aneurysms of patients of varying ages is limited. We present a multicenter study that aimed at determining age-dependent morphological characteristics of brain aneurysms.

Methods Unruptured and ruptured saccular aneurysms from the STAR registry were evaluated. Our analysis consisted of location, size, neck, width, height, aspect ratio, and regular versus irregular morphology. Logistic regression was utilized to estimate the risk of rupture presentation.

Results A total of 1407 unruptured and 607 ruptured aneurysms were included. The MCA and ACOM were the most common locations for ruptured aneurysms in patients younger than 70 years. Conversely, ACOM and PCOM were the most common locations for ruptured aneurysms in patients older than 70 years-old. The size of unruptured aneurysms increased among age groups (p < .001). However, size was similar among ruptured aneurysms of different age groups (p = .142). Unruptured and ruptured aneurysms became more irregular with age (p < .001 and p .025, respectively). Finally,ruptured aneurysms were more likely to be irregular in all age groups: 20-50 (OR = 3.9, 95% CI [2.0-4.7]); 51 -70 (OR = 1.9, 95% CI [1.5-2.6]); and 71-100 (OR = 3.4, 91% CI [2.2-5.4]).

Conclusion The morphology of saccular brain aneurysms is different among age groups. An irregular morphology is a high-risk feature regardless of age. In younger patients, aneurysms are smaller, tend to be more regular and ruptured aneurysms are mostly located in the MCA and ACOM. In older patients, aneurysms are larger, have a more irregular morphology and ruptured aneurysms are mostly located in the PCOM and ACOM.

Disclosures S. Sanchez: None. M. Essibayi: None. M. Hickerson: None. D. Ojeda: None. S. Al Kasab: None. S. Yoshimura: None. P. Jabbour: None. J. Mascitelli: None. M. Levitt: None. H. Cuellar-Saenz: None. W. Brinjikji: None. A. Spiotta: None. A. Shaban: None. E. Samaniego: None.

https://doi.org/10.1136/jnis-2023-SNIS.283

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