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O-033 Porcine dural venous sinus cadaveric assessment as an in-vivo model for venous sinus stenosis and stenting research
  1. D Heiferman1,
  2. S Ayock2,
  3. J Peterson3,
  4. V Nguyen4,
  5. C Nickele5
  1. 1Neurological Surgery, Northshore Edward-Elmhurst Health, Naperville, IL, USA
  2. 2University of Tennessee Health Science Center, Memphis, TN, USA
  3. 3Neurological Surgery, University of Kansas Health System, Kansas City, KS, USA
  4. 4Neurological Surgery, University of Southern California, Los Angeles, CA, USA
  5. 5Neurological Surgery, Semmes Murphey Clinic, Memphis, TN, USA


Introduction Despite the significant increase in utilization in dural venous sinus stenting, the underlying cause and pathophysiology of these stenoses remains poorly understood. In-vivo research has been lacking in this area, as there is currently no established animal model to study venous sinus stenosis and stenting. Recent studies have shown promise for the potential for a porcine model for this pathology.

Methods Craniotomies were performed on six adult pig heads slaughtered for food production. The dorsal sagittal and bilateral transverse-sigmoid sinuses were isolated. Each sinus length was measured. The dorsal sagittal sinus was sectioned at its midpoint. Vascular dilators, ranging from 3 French to 14 French were serially inserted into the anterior and posterior dorsal sagittal and bilateral transverse-sigmoid sinuses until resistance was met to assess their diameter.

Results Dorsal sagittal sinus length ranged from 8-9.5cm. Anterior dorsal sagittal sinus diameter ranged from 5-12 French and posterior ranged from 8-12 French. Right transverse-sigmoid sinus diameters ranged from 6-11 French and one was hypoplastic, and the left ranged from 4-12 French and one was hypoplastic.

Conclusion The porcine dural venous sinus system share some characteristics to human’s, including right and left variability, including hypoplastic sinuses, and the wider posterior dorsal (superior) sagittal sinus. With the relatively straight anatomy of the dorsal sagittal sinus, the minimum length of 8cm, and the posterior diameter measuring between 8-12 French (2.7-4.0mm), this anatomy may be suitable for the implantation of intravascular stents for the assessment of stent neointimalization within the dural venous sinus system.

Disclosures D. Heiferman: 4; C; Concierge Innovation, LLC. S. Ayock: None. J. Peterson: None. V. Nguyen: None. C. Nickele: 4; C; Concierge Innovation, LLC.

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