Introduction The ASSIST registry is a prospective, global registry that assessed clinical and procedural outcomes associated with various operator techniques for mechanical thrombectomy (MT) in acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) where Stryker Neurovascular devices were used for the first pass.
Aim of Study An analysis of the registry data aims to determine if procedural outcomes, including first-pass effectiveness, safety, and clinical outcomes, vary by clot location among the three MT techniques.
Methods ASSIST patients were grouped in three cohorts: Stent Retriever (SR) Classic [SR + Balloon Guide Catheter (BGC)], SR Combination [SR + Aspiration Catheter (AC) ± Pump + BCG or Long Sheath (LS)] and Direct Aspiration [AC ± Pump + BGC or LS]. The procedural endpoint of eTICI 2c or greater on the first pass was stratified by clot location (MCA-M1, MCA-M2 and ICA). Similar analyses were performed on the primary clinical endpoint (mRS 0–2 at Day 90) and other secondary and safety endpoints.
Results A total of 1492 patients met the ASSIST eligibility criteria. First pass eTICI scores across the three different techniques, stratified by clot location, will be presented. Stratification by clot location will be also provided for other procedural, clinical and safety endpoints.
Conclusion ASSIST provides insights into the effectiveness and safety of different MT techniques as stratified by clot location to improve reperfusion rates, functional outcomes and quality of life for AIS patients worldwide.
ClinicalTrials gov ID: NCT03845491
Disclosure of Interest DFV reports consultancy for Medtronic, paid lectures for Cerenovus, and a research grant by MicroVention (unrelated to this work). DSL is a consultant as imaging core lab for Cerenovus, Genentech, Medtronic, Rapid Medical, Stryker, Vesalio. LLP is a Principal Biostatistician employed by Stryker Neurovascular. All other authors report no disclosures.
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