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P081/218  Morphomechanical analysis of intracranial aneurysms
  1. Jacob Miller1,
  2. Sebastian Sanchez1,
  3. Adam Galloy2,
  4. Marco Nino2,
  5. Katherine Guijarro-Falcon1,
  6. Andres Gudino1,
  7. David Hasan3,
  8. Edgar Samaniego1;4;5
  1. 1University of Iowa, Department of Neurology, IOWA CITY, USA
  2. 2University of Iowa, Roy J Carver Department of Biomedical Engineering, IOWA CITY, USA
  3. 3Duke University, Department of Neurosurgery, Durham, USA
  4. 4University of Iowa, Department of Neurosurgery, IOWA CITY, USA
  5. 5University of Iowa, Department of Radiology, IOWA CITY, USA


Introduction It is unknown why aneurysm rupture occurs at a specific location in the aneurysm wall.

Aim of Study Perform a comprehensive analysis of brain aneurysms. This includes aneurysmal wall enhancement (AWE), computational fluid dynamics (CFD) and finite element analysis (FEA) of different areas of the aneurysm.

Methods Forty-seven unruptured saccular aneurysm were included in the study. 3T high resolution vessel wall imaging was performed. 3D Segmentations of the aneurysms were generated with 3D Slicer to assess: AWE using post-contrast signal intensity (SI) heatmaps; Wall Tension (WT) calculated from FEA; time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and wall shear stress gradient (WSSG) from CFD. A detailed compartmental analysis was performed.

Results Eighteen aneurysms were irregular and eleven had blebs. WT, TAWSS, and WSSG were higher in the neck compared to the dome (p<0.001, p=0.02 and p<0.001, respectively). Conversely, AWE and OSI were higher in the dome compared to the neck (p=0.01 and p=0.03, respectively). In aneurysms with blebs, WT, WSSG, and AWE were significantly different between the bleb, neck, and aneurysm body (p<0.001, p=0.04 and p=0.03, respectively). Blebs had the highest AWE in the aneurysm. However, the lowest points of WT and WSSG in the aneurysms were in the bleb.

Conclusion A comprehensive morphomechanical assessment may identify high risk areas of rupture within the aneurysm. Unstable areas, such as blebs, had a high AWE and low WSSG and WT. The morphomechanical features also differed in the aneurysm neck compared to the body.

Disclosure of Interest Nothing to disclose

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