Background Few studies have focused on the effect of systemic inflammation in vertebrobasilar artery occlusion (VBAO). The aim of this study was to investigate the relationship between inflammatory indicators and the prognosis of VBAO patients receiving endovascular treatment (EVT).
Method Patients with VBAO who were treated with EVT within 24 hours of the estimated occlusion time were included in this study. Multivariate logistic regression and elastic net regularization were performed to analyze the effects of inflammatory indicators on the prognosis of patients with VBAO. The primary outcome was unfavorable outcome (a modified Rankin Scale score of 4–6) at 90 days. Secondary outcomes included symptomatic intracranial hemorrhage, in-hospital mortality, 90 day mortality, 1 year unfavorable outcome, and mortality.
Results 560 patients were included in the study. Multivariate analysis showed that white blood cells (W), neutrophils (N), neutrophil to lymphocyte ratio (NLR), platelet to neutrophil ratio, platelet to white blood cell ratio, and NLR to platelet ratio were associated with the primary outcome. Elastic net regularization indicated that W, N, and NLR were the major inflammatory predictors of unfavorable outcome at 90 days. For long term prognosis, we found that the inflammatory indicators that predicted 1 year outcomes were consistent with those that predicted 90 day outcomes.
Conclusion Inflammatory indicators, especially W, N, and NLR, were associated with moderate and long term prognosis of patients with VBAO treated with EVT.
- Inflammatory Response
Data availability statement
Data are available upon reasonable request.
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PZ and PX contributed equally.
Contributors The study was conceived by PZ, PX, JW, and WS. PZ prepared the initial draft of the manuscript. PZ and PX carried out the statistical analysis. PZ, JW, and WS revised the manuscript. WS is responsible for the overall content as guarantor. All authors participated in the data collection, analysis, and interpretation. The final version of the manuscript was approved by all authors.
Funding The study was supported by grants from Key Research and Development Plan Projects of Anhui Province No 202104j07020049 and Natural Science Foundation of Anhui Province No 2108085MH271.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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