You are here

Article Text

Article menu
Download PDFPDF
Ischemic stroke
Original research
Basilar artery occlusion location and clinical outcome: data from the ATTENTION multicenter registry
  1. Shuai Yu1,2,
  2. Xiaocui Wang1,
  3. Zhiliang Guo1,
  4. Pengfei Xu3,
  5. Chunrong Tao3,
  6. Rui Li3,
  7. Wei Hu3,
  8. Guodong Xiao1
  1. 1 Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China
  2. 2 Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China
  3. 3 Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People's Republic of China
  1. Correspondence to Prof Guodong Xiao; yarrowshaw{at}hotmail.com; Prof Wei Hu; andinghu{at}ustc.edu.cn

Abstract

Background Acute basilar artery occlusion is a disabling and life-threatening condition. The purpose of this study was to evaluate the impact of occluded vessel location on the prognostic outcomes of patients who underwent endovascular treatment for acute basilar artery occlusion.

Methods Patient data for this study were obtained from the ATTENTION registry. Baseline data of the patients were described and compared across different occlusion locations. Univariable and multivariable regression analyses were performed to assess the effect of occluded vessel location on associated prognostic outcomes.

Results A total of 1672 patients were included in the analysis, with 583 having distal occlusion, 540 having middle occlusion, and 549 having proximal occlusion. Unlike distal occlusion, both proximal and middle occlusions were significantly and negatively associated with favorable clinical outcomes (for modified Rankin Scale score 0–3: adjusted odds ratio (aOR) 0.634, 95% confidence interval (95% CI) 0.493 to 0.816, P<0.001 in middle occlusion, and aOR 0.620, 95% CI 0.479 to 0.802, P<0.001 in proximal occlusion). Mortality was higher in patients with proximal and middle occlusions (aOR 1.461, 95% CI 1.123 to 1.902, P=0.005 in middle occlusion, and aOR 1.648, 95% CI 1.265 to 2.147, P<0.001 in proximal occlusion). The occluded vessel location was not associated with symptomatic intracranial hemorrhage.

Conclusions Proximal and middle basilar artery occlusions were predominantly associated with poor clinical outcomes and increased risk of death following endovascular treatment.

  • Intervention
  • Stroke
  • Thrombectomy

Data availability statement

Data are available upon reasonable request. Data are available upon reasonable request. Datasets acquired and analyzed during the study are available from the corresponding author on request.

https://doi.org/10.1136/jnis-2023-020517

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Data availability statement

    Data are available upon reasonable request. Data are available upon reasonable request. Datasets acquired and analyzed during the study are available from the corresponding author on request.

    View Full Text

    Footnotes

    • SY, XW and ZG contributed equally.

    • Contributors Shuai Yu, Xiao-cui Wang and Zhi-liang Guo were involved in writing and revising the manuscript. Shuai Yu analyzed the data. Peng-fei Xu, Chun-rong Tao, Rui Li had full access to all data in the study and take responsibility for the integrity and accuracy of the data. Guo-dong Xiao and Wei Hu led the study and participated in critical revision of the manuscript. All the authors strictly reviewed the article and approved the final version. GX acted as the guarantor of the study.

    • Funding This work has been supported in part by these grants: the Suzhou Science and Technology Bureau Medical-Industrial Collaborative Innovation Research Project (SLJ2021014) and the Suzhou Medical and Health Science and Technology Innovation (SKY2022160).

    • Competing interests There are no potential conflicts of interest to disclose between the authors.

    • Provenance and peer review Not commissioned; externally peer reviewed.