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Basic science
Original research
WEB shape modifications: angiography–histopathology correlations in rabbits
  1. Kevin Janot1,
  2. Grégoire Boulouis1,
  3. Géraud Forestier2,
  4. Fouzi Bala1,
  5. Jonathan Cortese3,4,
  6. Zoltán Szatmáry4,
  7. Sylvia M. Bardet4,
  8. Maxime Baudouin5,
  9. Marie-Laure Perrin4,
  10. Jérémy Mounier4,
  11. Claude Couquet4,
  12. Catherine Yardin6,
  13. Guillaume Segonds7,
  14. Nicolas Dubois7,
  15. Alexandra Martinez7,
  16. Pierre-Louis Lesage7,
  17. Yong-Hong Ding8,
  18. Ramanathan Kadirvel8,
  19. Daying Dai8,
  20. Charbel Mounayer2,
  21. Faraj Terro9,
  22. Aymeric Rouchaud2,4
  1. 1 Interventional Neuroradiology, University Hospital of Tours, Tours, France
  2. 2 Interventional Neuroradiology, University Hospital of Limoges, Limoges, France
  3. 3 NEURI The Brain Vascular Center, Bicêtre University Hospital, Le Kremlin-Bicêtre, France
  4. 4 XLIM UMR CNRS 7252, University of Limoges, Limoges, France
  5. 5 Radiology, University Hospital of Limoges, Limoges, France
  6. 6 Histology, Cytology, Cellular Biology and Cytogenetics, University Hospital of Limoges, Limoges, France
  7. 7 University of Limoges, Limoges, France
  8. 8 Radiology, Mayo Clinic, Rochester, Minnesota, USA
  9. 9 Cell Biology, University Hospital of Limoges, Limoges, France
  1. Correspondence to Dr Kevin Janot, Diagnostic and Interventional Neuroradiology, University Hospital of Tours, Tours, France; kevin.janot{at}hotmail.com

Abstract

Background WEB Shape Modification (WSM) over time is frequent after aneurysm treatment. In this study, we explored the relationship between histopathological changes and angiographic evolution over time in experimental aneurysms in rabbits treated with the Woven EndoBridge (WEB) procedure.

Methods Quantitative WSM was assessed using flat-panel computed tomography (FPCT) during follow-up by calculating height and width ratio (HR, WR), defined as the ratio between either measurement at an index time point and the measurement immediately after WEB implantation. The index time point varied from 1 day to 6 months. HR and WR were evaluated with angiographic and histopathological assessments of aneurysm healing.

Results Final HR of devices varied from 0.30 to 1.02 and final WR varied from 0.62 to 1.59. Altogether, at least 5% of HR and WR variations were observed in 37/40 (92.5%) and 28/40 (70%) WEB devices, respectively, at the time of final assessment. There was no significant correlation between complete or incomplete occlusion groups and HR or WR (p=0.15 and p=0.43). Histopathological analysis revealed a significant association between WR and aneurysm healing and fibrosis 1 month following aneurysm treatment (both p<0.05).

Conclusion Using longitudinal FPCT assessment, we observed that WSM affects both the height and width of the WEB device. No significant association was found between WSM and aneurysm occlusion status. Although presumably a multifactorial phenomenon, the histopathological analysis highlighted a significant association between width variations, aneurysm healing and fibrosis in the first month following aneurysm treatment.

  • Aneurysm

Data availability statement

Data are available upon reasonable request.

https://doi.org/10.1136/jnis-2023-020193

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    Data availability statement

    Data are available upon reasonable request.

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    Footnotes

    • Twitter @gboulouis, @FouziBala

    • Contributors KJ conceived and composed the initial draft manuscript framework, acquired the data, wrote the original draft and is responsible for the overall content as the guarantor ; GB, AR, FB were responsible for writing, reviewing and editing the manuscript; GF, JC, ZS, SMB, MB, MLP, JM, CC,CY, ND, GS, AM, PLL,YHD, RK, DD, CM, FT all reviewed and edited the draft. All authors approved of the final version of the manuscript before submission for publication.

    • Funding WEB devices used for this work are provided by Microvention. This work was partially supported by Microvention and the French Radiology Society.

    • Competing interests AR reports consulting for Balt and Microvention.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.