Article Text

Download PDFPDF
Correspondence on ‘Acute ischemic stroke outcomes in patients with COVID-19: a systematic review and meta-analysis’ by Ferrone et al
  1. Tayyab Muzaffar1,2,
  2. Ahmad Danial2,
  3. Muhammad Khaleeq Ahmed3,4
  1. 1 Department of Neurology, Quaid-e-Azam Medical College, Islamabad, Pakistan
  2. 2 Quaid-e-Azam Medical College, Bahawalpur, Pakistan
  3. 3 Department of Neurology, Augusta University, Rome, Georgia, USA
  4. 4 Department of Neurology, Medical College of Georgia, Augusta, Georgia, USA
  1. Correspondence to Dr Muhammad Khaleeq Ahmed, Department of Neurology, Augusta University, Rome, GA 30912, USA; dr.k.ahmed2{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

We had the pleasure of reading the article ‘Acute ischemic stroke outcomes in patients with COVID-19: a systematic review and meta-analysis’ by Ferrone et al. with great interest.1 In particular, the reduced odds of home discharge for patients with stroke who have COVID-19 presents an interesting insight into the management challenges while caring for these patients.

However, we would like to highlight some concerns about the methodology of the study. Heterogeneity is defined as observed intervention effects being more different from each other than one would expect due to random error (chance) alone.2 For the outcomes of in-hospital mortality and discharge modified Rankin Scale (mRS) score 0–2 the heterogeneity (I2) was 86.7% (P<0.001) and 93.0% (P<0.001), respectively, which is regarded as considerable (75– 100%). …

View Full Text


  • Twitter @TayyabMuza, @@mkhaleeqahmed

  • Contributors All author contributed to manuscript formation, review, and reference gathering.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

Linked Articles

  • The pandemic and neurointervention
    Sophia R Ferrone Maria X Sanmartin Joseph Ohara Jean C Jimenez Chinara Feizullayeva Zachary Lodato Shaya Shahsavarani Gregory Lacher Seleshi Demissie Jaclyn Morales Vialet Tim G White Jason J Wang Jeffrey M Katz Pina C Sanelli