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E-108 Use of Onyx Frontier for intracranial stenting in stroke patients: a multicenter retrospective study
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  1. A Chahine
  1. Neurology, University of Chicago Medical Center, Chicago, IL

Abstract

Background Acute ischemic stroke (AIS) due to intracranial atherosclerotic disease (ICAD) can be challenging to treat. Novel technical approaches, such as the Onyx Frontier stent (Medtronic, Santa Rosa, CA), are emerging. The aim of our multicenter study is to present our initial experience with the Onyx Frontier balloon-mounted drug-eluting stent for AIS due to ICAD.

Methods We conducted a multicenter retrospective case series describing the technical feasibility and performance of using the Onyx Frontier balloon-mounted drug-eluting stent in patients with AIS due to ICAD across three comprehensive stroke centers in the United States.

Results We included 23 patients in our study (mean age 67.3 [10.7]; females: n=13/23, 56.5%). The majority of patients were African American/Black (n=14/23, 60.9%). The most common site of vessel occlusion was the M1 branch of the middle cerebral artery (MCA) (n=14/23, 60.9%), followed by the vertebrobasilar system (n=5/23, 21.7%), and the internal carotid artery (n=3/23, 13.0%). There was a single case of M2 MCA occlusion. All stent embolization procedures were successfully treated with the Onyx Frontier zotarolimus-eluting stent. None of the patients had any restenosis or re-treatment. All cases required a single stent except for one, where two were implanted. Transfemoral access was used in most cases (n=18/23, 78.3%), with one in-hospital death due to access site complication (n=1/23, 4.3%).

Conclusions This is the largest multicenter case series demonstrating the feasibility and safety of using the Onyx Frontier balloon-mounted zotarolimus-eluting stent to treat symptomatic AIS due to ICAD.

Disclosures A Chahine: None.

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