Background Diffuse correlation spectroscopy (DCS) is a noninvasive optical technique that enables continuous blood flow measurements in the brain. DCS quantitatively measures blood flow from temporal fluctuations in the intensity of diffusely reflected light caused by the dynamic scattering of light from moving red blood cells within the tissue.

Methods We performed bilateral cerebral blood flow (CBF) measurements using a custom DCS device in patients undergoing carotid artery stenting. Experimental, clinical, and imaging data were collected in a prospective manner.

Results The device was successfully applied in five subjects. There were no safety concerns or interference with the standard angiography suite or intensive care unit workflow. We found an association between angiographic changes in the degree of stenosis (baseline versus post angioplasty/stenting) and those observed intraprocedurally with CBF measurements via DCS; (figure 1). Correlation between the angiographic degree of stenosis, severity of stenosis using carotid doppler ultrasound, and CBF changes will be included in the final presentation.

Conclusions We observed an association between abnormal radiographic findings and real-time CBF measurements during carotid artery stenting, confirming the feasibility of this diagnostic modality. Its potential applications in clinical practice may include early diagnosis of reperfusion injury, hypoperfusion states and ischemia.

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Abstract E-285 Figure 1

Disclosures A. Letavay: None. S. Amin: None. W. Guerrero: None. K. Vakharia: None. V. Raghu: None. P. Mohammad: None. A. Parthasarathy: 1; C; NIH. 4; C; SPKL LLC. M. Mokin: 1; C; NIH - R21NS130495. 2; C; Balt, Cerenovus, Medtronic, Rapid Pulse. 4; C; Bendit Technologies, Borvo Medical, BrainQ, EndoStream, Radical Catheter Technologies, Serenity Medical, Synchron, Sim&Cure, QAS.AI, Quantanosis. AI.