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Abstracts
Ischemic
2.3. Treatment
P137 Main trial results of the EVAQ clinical study for the Q revascularization system in acute ischemic stroke
Free
  1. Christophe Cognard1,
  2. Brian Jankowitz2,
  3. Lucas Elijovich3,
  4. Benjamin Gory4,
  5. Romain Bourcier5,
  6. Xavier Barreau6,
  7. Federico Di Maria7,
  8. Laurent Spelle8,
  9. Maxim Mokin9,
  10. Adnan Siddiqui10,
  11. Jazba Soomro11,
  12. Omer Eker12,
  13. Clemens Schirmer13,
  14. Ashutosh Jadhav14,
  15. Hamza Shaikh15,
  16. Charles Matouk16,
  17. Michael Stiefel17,
  18. M Taqi18,
  19. Jean Darcourt19,
  20. Leon Ikka20,
  21. Gaultier Marnat6,
  22. Kunal Vakharia9,
  23. Guillaume Bellanger19,
  24. Florent Gariel6,
  25. Alessandro Sgreccia7,
  26. Pierre Louis Alexandre5,
  27. Liang Liao21,
  28. Morgane Laubacher22,
  29. Jason Davies10,
  30. Anne-Christine Januel19,
  31. Hubert Desal5,
  32. Osman Mir11,
  33. Roberto Riva22,
  34. Silvia Pizzuto7,
  35. David Liebeskind23
  1. 1Hôpital Purpan, CHU de Toulouse, Tousouse, France
  2. 2JFK University Medical Center, Edison, USA
  3. 3Semmes Murphey, Memphis, USA
  4. 4CHRU de Nancy, NANCY, France
  5. 5CHU de Nantes, Nantes, France
  6. 6University Hospital of Bordeaux, Bordeaux, France
  7. 7Hospital Foch, Suresnes, France
  8. 8Bicetre Medical Center, Bicetre, France
  9. 9University of South Florida, Tampa General, Tampa, USA
  10. 10University at Buffalo, Jacobs Institute, Buffalo, USA
  11. 11Texas Stroke Institute, Plano, USA
  12. 12Hospices Civils de Lyon, Bron, France
  13. 13Geisinger, Wilkes-Barre, USA
  14. 14Barrow Neurological Institute, Phoenix, USA
  15. 15Cooper University Healthcare, Camden, USA
  16. 16Yale University, New Haven, USA
  17. 17Piedmont Health, Atlanta, USA
  18. 18Vascular Neurology of Southern California, Thousand Oaks, USA
  19. 19Hopital Purpan, CHU de Toulouse, Toulouse, France
  20. 20Bicetre Hospital, Bicetre, France
  21. 21CHRU de Nancy, Nancy, France
  22. 22CHU Lyon, Bron, France
  23. 23Neurovascular Imaging Research Core, UCLA, Los Angeles, USA

Abstract

Introduction The Q Revascularization System is a novel thrombectomy device which aims to improve aspiration efficacy by increasing the system inner diameter. The larger diameter allows for greater impulse and acceleration of aspiration than traditional aspiration systems.

Abstract P137 Figure 1
Abstract P137 Figure 1
View this table:
Abstract P137 Table 1

Catheter system average inner diameter (ID)

Aim of Study Report the results of the EVAQ clinical study,

Methods EVAQ is a prospective, single arm study with CEC and Core Lab assessed endpoints studying Q for the primary treatment of LVOs within 8hrs of symptom onset. Primary efficacy and safety endpoints are final mTICI2b-3 and sICH. Pre-specified secondary endpoints include revascularization after use of Q, first pass reperfusion and mRS0-2 at 90 days.

Results The EVAQ study enrolled one hundred twenty-three subjects at 17 centers in France and the US from November 2020 to April 2023. Mean age was 68.3. Females were 52.8%. Mean NIHSS and ASPECTS were 15.8±5.9 and 8.1±1.5 respectively. Sites of large vessel occlusion treatment were Basilar 3.3%, ICA 13.9%, M1 MCA 64.2%, M2 MCA 17.1%, and other anterior location 1.6%. IV thrombolysis was administered in 55.5% of subjects. Onset to arterial puncture was 4.58 hours ±2.04.

The primary outcome, final mTICI2b-3 by independent imaging core lab, was achieved in 93.9% of subjects. CEC adjudicated sICH per ECASS was 6.5%. Revascularization after the use of Q alone was 78.8% and first pass success was 56.7%. Time from groin puncture to successful revascularization was a mean of 38.2 minutes.

Conclusion The novel Q Revascularization System is safe and effective for revascularization of Large Vessel Occlusions in acute ischemic stroke.

Disclosure of Interest no.

https://doi.org/10.1136/jnis-2024-ESMINT.173

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