Introduction Timely intervention is paramount in managing acute large vessel occlusion (LVO), yet in-hospital delays often impede treatment efficacy and patient outcomes.

Aim of Study To explore the impact of time intervals on functional outcomes in patients with acute LVO

Methods A total of 68 patients (38males and 30females), aged 44-90 years, were analyzed retrospectively. Neurological deficits were assessed using the National Institutes of Health Stroke Scale (NIHSS), categorizing them as severe(>15) or moderate(5-15). Functional outcomes were evaluated using the Modified Rankin Scale, where lower scores(0-3) denote favorable outcomes and higher scores(4-6) indicate unfavorable ones. Onset-to-admission and admission-to-groin puncture times were assessed.

Results The mean onset-to-admission time ranged from 25-to-300 minutes, while admission-to-puncture time ranged from 50-to-170 minutes. A shorter onset-to-admission time (97.9±8.7min vs. 131.7±12.6min, p=0.05) was associated with favorable functional outcomes. Similarly, patients with favorable outcomes had a shorter admission-to-puncture time than those with unfavorable outcomes (75.5±4.1min vs. 94.8±5.7min, p=0.01). Patients with severe neurological deficits on admission experienced longer door-to-puncture times (91.9±5.9) compared to those with NIHSS≤15 (77.2±6.1min, p=0.10).

Conclusion This study underscores the critical significance of timely intervention in acute LVO, aligning with recommended guidelines for swift treatment initiation. Early hospitalization and expedited groin puncture, without emergency department delays, significantly improved functional outcomes. However, challenges such as longer door-to-puncture times in patients with severe neurological deficits highlight the need for targeted interventions to address system inefficiencies. Future research should focus on identifying modifiable factors influencing time intervals and implementing streamlined protocols to minimize delays and optimize treatment efficiency in acute LVO