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Abstract
Introduction Turner syndrome is a chromosomal disorder is associated with a range of comorbidities involving the cardiovascular system which affects both pediatric and adult patients. Vascular abnormalities, including aortic dilatation, aortic dissection, aortic coarctation, are a common finding in cases of Turner syndrome. However, cerebral aneurysm presenting aneurysmal subarachnoid hemorrhage is rare. The exact cause and the underlying molecular biology of the aneurysm formation and growth and development of SAH of this patient, was unknown. It was most likely rupture of dilated vessels stemming from the vasculopathy.
Case Description The subject of this report was a 34-year-old female presented with sudden severe headache. She had a previous medical history with Turner syndrome 20 years ago, managed with medical treatment including estrogen hormone replacement therapy. At an admission, computed tomography revealed that subarachnoid hemorrhage was located in the basal cistern (figure 1-A). Cerebral angiography demonstrated a saccular aneurysm of the right anterior communicating artery (figure 1-B,C). The aneurysm was treated by an endovascular coil embolization (figure 2-A,B). During her admission, she had a genetic analysis. It results that an one normal X chromosome is present in a female’s cells and the other sex chromosome is missing or structurally altered compatible with Turner syndrome (figure 3-A).
Results We should recognize the fact that Turner syndrome cases are susceptible to renovascular hypertension. Both renovascular hypertension and cerebral vascular abnormality may play roles in the occurrence of the cerebral vascular incidents.
Disclosure of Interest no.