Article Text

Download PDFPDF
Novel use of prasugrel for intracranial stent thrombosis
  1. Thabele M Leslie-Mazwi1,
  2. Ronil V Chandra1,
  3. Daniel C Oh1,
  4. Raul G Nogueira2
  1. 1Department of Interventional Neuroradiology/Endovascular Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
  2. 2Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA
  1. Correspondence to Thabele M Leslie-Mazwi, Department of Interventional Neuroradiology/Endovascular Neurosurgery, 2-214 Gray/Bigelow, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA; tleslie-mazwi{at}


Dual antiplatelet therapy is established for prevention of stent thrombosis in cardiac patients, and widely utilized in neurointerventional stent cases. Aspirin and clopidogrel are typically synergistic. We present a case of clopidogrel resistance due to genetic polymorphism resulting in acute stent thrombosis during elective stent-assisted coiling, with novel use of prasugrel as an alternative platelet inhibitor in the neurovascular setting.

  • Aneurysm
  • artery
  • coiling
  • complication
  • prasugrel
  • stent
  • thrombosis

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests None to declare.

  • Provenance and peer review Not commissioned; externally peer reviewed.