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Hemorrhagic stroke
Novel use of prasugrel for intracranial stent thrombosis
  1. Thabele M Leslie-Mazwi1,
  2. Ronil V Chandra1,
  3. Daniel C Oh1,
  4. Raul G Nogueira2
  1. 1Department of Interventional Neuroradiology/Endovascular Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
  2. 2Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA
  1. Correspondence to Thabele M Leslie-Mazwi, Department of Interventional Neuroradiology/Endovascular Neurosurgery, 2-214 Gray/Bigelow, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA; tleslie-mazwi{at}partners.org

Abstract

Dual antiplatelet therapy is established for prevention of stent thrombosis in cardiac patients, and widely utilized in neurointerventional stent cases. Aspirin and clopidogrel are typically synergistic. We present a case of clopidogrel resistance due to genetic polymorphism resulting in acute stent thrombosis during elective stent-assisted coiling, with novel use of prasugrel as an alternative platelet inhibitor in the neurovascular setting.

  • Aneurysm
  • artery
  • coiling
  • complication
  • prasugrel
  • stent
  • thrombosis

https://doi.org/10.1136/jnis.2010.004382

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    Footnotes

    • Competing interests None to declare.

    • Provenance and peer review Not commissioned; externally peer reviewed.