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Original research
Younger age of menopause in women with cerebral aneurysms
  1. Christine Ding1,
  2. Valerie Toll2,
  3. Bichun Ouyang2,
  4. Michael Chen2
  1. 1University of Illinois Chicago College of Medicine, Chicago, Illinois, USA
  2. 2Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
  1. Correspondence to Dr Michael Chen, Department of Neurological Sciences, Rush University Medical Center, 1725 West Harrison Street Suite 1121, Chicago, IL 60612, USA; michael_chen{at}


Background The incidence of subarachnoid hemorrhage in women surges following menopause. Estrogen fluctuations have been implicated in cerebral aneurysm formation, growth and rupture and are thought to explain the well-known gender disparity. The aim of this study was to examine the association between age at menopause, which can determine lifetime estrogen exposure, and the presence of cerebral aneurysms.

Methods A retrospective case-control study was conducted by interviewing postmenopausal women with intradural cerebral aneurysms about their basic medical and gynecologic histories. This information was compared with the same data points collected from 4682 women contacted through random digit phone dialing in the National Institute of Child Health and Human Development-sponsored Contraceptive and Reproductive Experiences Study published in 2002.

Results Among 76 consecutive postmenopausal women with cerebral aneurysms who were treated by a single physician and interviewed, multivariate logistic regression showed that later menopause age (OR 0.79, CI 0.63 to 0.996, p=0.046) was significantly associated with a lower aneurysm incidence. Premature menopause (<40 years) was seen in 26% of cases and 19% of controls (p=0.15). Each categorical increase in menopause age (<40, 40–44, 45–49, 50–54, ≥55 years) decreased the likelihood by 21%. Despite a trend towards earlier mean age at menopause in the case group, the difference was not statistically significant.

Conclusion There is a trend showing that an earlier age at menopause is associated with the presence of a cerebral aneurysm. This suggests that loss of estrogen earlier in a woman's life may contribute to the pathogenesis of cerebral aneurysm. These data may identify a risk factor for cerebral aneurysm pathogenesis and also a potential target for future therapies.

  • Aneurysm
  • estrogen
  • menopause
  • neuroendovascular surgery
  • stroke
  • subarachnoid
  • brain
  • arteriovenous malformation
  • technique
  • vessel wall

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  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by Rush University Medical Center IRB (11072602-IRB01).

  • Provenance and peer review Not commissioned; externally peer reviewed.