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Original research
Initial experience with Penumbra Coil 400 versus standard coils in embolization of cerebral aneurysms: a retrospective review
  1. Justin R Mascitelli,
  2. Maritsa F Polykarpou,
  3. Aanand A Patel,
  4. Ashwin A Kamath,
  5. Henry Moyle,
  6. Aman B Patel
  1. Department of Neurosurgery, Mount Sinai School of Medicine, New York, New York, USA
  1. Correspondence to Dr A B Patel, Department of Neurosurgery, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1136, New York, NY 10029, USA; aman.patel{at}


Background and purpose The Penumbra Coil 400 System (PC 400) is the newly introduced platinum coil system designed specifically to enhance filling efficiency by increasing coil diameter. Our goal was to study the packing and treatment advantage of the PC 400's unique geometric configuration compared with conventional coils (controls).

Materials and methods 16 aneurysms embolized with the PC 400 in 2011 were compared with 79 equally matched aneurysms embolized with conventional coils from 2004 to 2011. Primary outcomes assessed were acute packing density, embolization time, and the number of coils required for aneurysm occlusion.

Results Aneurysm embolization with the PC 400 achieved a higher packing density (36.8% vs 28.1%; p<0.005) and with fewer coils (an average of 3.9 vs 6.1 coils per aneurysm; p<0.05). In addition, the total procedural time for the subjects treated with the PC 400 was significantly less (45.7 vs 64.1 min;  p<0.05). There were no procedural complications associated with the PC 400.

Conclusions Compared with conventional coils, the PC 400 is more efficient in the embolization of cerebral aneurysms, achieving greater packing density with fewer coils and less time without compromising safety.

  • Aneurysm
  • Embolic
  • Brain
  • Coil
  • Device

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