Purpose To evaluate tissue reaction induced by a newly developed bioactive coil material, which is made of bare platinum core coated with ultrathin polymer with accelerated degradation speed and increased acidity, expecting to accelerate thrombus organisation. Experimental aneurysms treated with the novel coil materials were compared with the aneurysms treated with bare platinum coil (GDC) and currently available polymeric coil material (Matrix II ®).
Materials and Methods A swine aneurysm model, which was designed to perform quantitative analysis of histologic changes induced by the implanted coil materials, was used in this study. The novel coil materials, which was composed of a bare platinum core covered with an ultrathin - micron level - polymer coating composed of acidified 50/50 polyglicolic-polylactic acid (PGLA) was implanted in 4 experimental swine aneurysms (group A). Four aneurysms were treated with Matrix II® (group B) and 4 were treated with GDCs (group C). Fourteen days after the implantation, each aneurysm was harvested and histologic analysis of each sample was performed.
Results Histologic findings showed the most advanced thrombus organisation - characterised by dense collagen deposition and prominent fibroblast migration - was observed in aneurysms of group A, followed by group B and C. The most prominent inflammatory reaction adjacent to the coil material at Day 14 was seen in group B, followed by group A and group C. However, group A showed a high degree of collagen organisation with little immature thrombus remaining, indicative of late stage aneurysm healing.
Conclusion The novel bioactive coil material with ultrathin acidified 50/50 PGLA coating may accelerate the thrombus organisation in the experimental aneurysms as compared to the currently available coil materials for brain aneurysm treatment.
Disclosures I. Yuki: 1; C; Stryker Grant. A. Suwarnasarn: 1; C; Stryker Grant. I. Kan: None. M. Fujimoto: None. F. Mayor: None. H. Vinters: None. R. Kim: None. F. Vinuela: None. Y. Murayama: None. B. Wu: 1; C; Stryker Grant. F. Vinuela: 1; C; Stryker Grant.
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