Article Text

Download PDFPDF
E-067 Permeability Surface Product as a Predictor of Haemorrhagic Transformation in Acute Ischaemic Stroke Intervention
  1. A Matthews1,
  2. M Parker1,
  3. N Rutledge2,
  4. K Conrad2,
  5. J Luci1,
  6. B Bluett3
  1. 1College of Natural Sciences, The University of Texas at Austin, Austin, TX
  2. 2Neurointerventional Surgery, Austin Radiological Association, Austin, TX
  3. 3UT Southwestern Austin Neurology Residency Program, University Medical Center Brackenridge, Austin, TX


Introduction/Purpose A significant complication in the intervention of acute ischaemic stroke is haemorrhagic transformation. It has been postulated that perfusion permeability imaging showing increased blood brain barrier permeability can be used to predict haemorrhagic transformation and possibly alter therapies.

Materials and Methods We retrospectively reviewed 60 CT perfusion scans with permeability surface area product maps calculated using the Patlak model where IV tPA or endovascular thrombectomy was performed at our institution in 2012.

Results Permeability maps were positive in 31 of the 60 cases. The size of the permeability change was medium to large in 29 of 31 cases (94%). Of the positive permeability cases only two (6%) subsequently developed haemorrhagic transformation (HT). One was a PH2 haemorrhage and one a HI2 haemorrhage. Both cases where HT occurred were successful (TICI 2b/3) endovascular thrombectomies. Neither of these cases developed malignant oedema, required hemicraniotomy or other intervention. No difference was found in the size or degree of the permeability changes and the incidence of HT.

Conclusion Elevated permeability on CT perfusion imaging had no relevant predictive value for haemorrhagic transformation in acute ischaemic stroke interventions at our institution.

Disclosures A. Matthews: None. M. Parker: None. N. Rutledge: None. K. Conrad: None. J. Luci: None. B. Bluett: None.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.