Objective To evaluate the safety and efficacy of flow-diversion for treatment of large and complex middle cerebral artery (MCA) aneurysms

Method We conducted a retrospective review of the clinical charts of all patients who underwent PED placement for aneurysm at our institution from October 2010 to October 2013. We included 10 patients of which 5 had large MCA aneurysms and 3 had giant ones. Fusiform unruptured aneurysms represented 7 of all 10 aneurysm. Angiographic and clinical follow-up were available for all patients mostly between 7 and 12 months.

Results We had no technical complications, no periprocedural morbidity and mortality. On follow-up we had no hemorrhagic complication, no aneurysm rupture and only one clinically significant thromboembolic event in a patient who discontinued antiplatelet therapy against medical advice. One patient had completely occluded his diseased vessel but remained asymptomatic. The overall complication rate is 3/10. On follow-up complete occlusion occurred in 7 patients (7/9).

Conclusion PED treatment for large, giant and bifurcation MCA aneurysms was feasible, with satisfying complete-occlusion rate, no mortality and reasonable morbidity rate.

Disclosures M. Zanaty: None. N. Chalouhi: None. S. Tjoumakaris: None. L. Gonzalez: None. R. Rosenwasser: None. P. Jabbour: None.