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Original research
Comparison of four different collateral scores in acute ischemic stroke by CT angiography
  1. Fatih Seker,
  2. Arne Potreck,
  3. Markus Möhlenbruch,
  4. Martin Bendszus,
  5. Mirko Pham
  1. Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany
  1. Correspondence to Dr Fatih Seker, Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg 69120, Germany; fatih.seker{at}


Purpose Multiple scores have been described for the assessment of collateralization in acute ischemic stroke. Currently, there is no gold standard for collateral assessment by CT angiography (CTA). This study compared four frequently used collateral scores with regard to their correlation with early infarct core and mismatch ratio.

Methods 30 consecutive patients with acute occlusion of the M1 segment or terminal carotid artery were reviewed retrospectively. Collaterals were assessed using dynamic and also single-phase CTA according to grading systems by the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR), Alberta Stroke Program Early CT Score (ASPECTS) (on collaterals), Christoforidis et al and Miteff et al. The Christoforidis and ASITN/SIR scores, which were initially designed for conventional angiography, were adapted to be applicable to CTA. The scores were compared with respect to early infarct core and mismatch ratio in perfusion CT estimated by RAPID software using Spearman correlation.

Results ASITN/SIR and ASPECTS collateral scores showed good correlation with early infarct core (rho=−0.696, p<0.001 and rho=−0.677, p<0.001) and mismatch ratio (rho=0.609, p<0.001 and rho=0.581, p<0.001). In contrast, the Christoforidis and Miteff scores correlated less well with infarct core (rho=0.245, p=0.191 and rho=−0.272, p=0.145, respectively) and mismatch ratio (rho=−0.329, p=0.075 and rho=0.279, p=0.135, respectively). ASPECTS and ASITN/SIR showed excellent cross-correlation (rho=0.901, p<0.001).

Conclusions Compared with the Christoforidis and Miteff scores, the modified ASITN/SIR and ASPECTS collateral scores showed consistently higher correlation with the extent of early infarct core and mismatch volume. This is probably because these scores evaluate the extent and delay of vascular enhancement in the affected territory rather than the backflow of contrast medium to the occlusion.

  • Stroke
  • CT Angiography
  • CT perfusion

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  • The abstract of this manuscript has been published in an abstract book.

  • Contributors FS conceived the study. FS, MM, MB, and MP initiated the study design. AP helped to conduct the statistical analysis. All authors contributed to the refinement of the study protocol and reviewed and approved the final manuscript.

  • Competing interests None declared.

  • Ethics approval Ethics approval was obtained from the Institutional Review Board of Heidelberg University.

  • Provenance and peer review Not commissioned; externally peer reviewed.