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Original research
Emergent mechanical thrombectomy for acute stroke using the Mindframe Capture LP system: initial single-center experience
  1. Russell Cerejo,
  2. Seby John,
  3. Andrew Bauer,
  4. Muhammad S Hussain,
  5. Mark Bain,
  6. Peter Rasmussen,
  7. Ferdinand Hui,
  8. Thomas Masaryk,
  9. Gabor Toth
  1. Cerebrovascular Center, Cleveland Clinic, Cleveland, Ohio, USA
  1. Correspondence to Dr Gabor Toth, Cerebrovascular Center, Cleveland Clinic, 9500 Euclid Ave, S80, Cleveland OH 44195, USA; tothg{at}


Background Mechanical thrombectomy using stentrievers is the standard of care for emergent large vessel occlusion stroke. Data on the use of stentrievers in smaller caliber vessels are sparse.

Objective To present our initial experience with the Mindframe Capture LP device, which was designed for mechanical thrombectomy in small cerebral arteries.

Methods A retrospective chart review was conducted of patients who underwent Mindframe device assisted emergent thrombectomy. Clinical, imaging, procedural and early follow-up data were obtained.

Results Nine patients met inclusion criteria (5 men, median age 62 years). Median National Institute of Health Stroke Scale (NIHSS) score was 18 (IQR 9–22), and 6 patients received intravenous tissue plasminogen activator. Six patients had M2 segment occlusions, and 2 patients had distal M1 segment occlusions of the middle cerebral artery. One had distal basilar artery occlusion. Median vessel diameter at the thrombus was 1.7 mm (IQR 1.5–2.5). In all 9 patients the Mindframe device was used together with manual aspiration, with median groin puncture to recanalization time of 35 min (IQR 27–54), and median procedural time of 67 min (IQR 51–91). Final Thrombolysis in Cerebral Infarction score was 3 and 2b in 4 patients each (89% total), and 2a in 1 patient. No patient had any postprocedural complications or symptomatic intracerebral hemorrhage. Median postprocedure and discharge NIHSS were 4 and 1, respectively.

Conclusions Our data suggest that the Mindframe device is safe and effective for rapid treatment of acute strokes involving small caliber intracranial vessels. Further study in a larger cohort is warranted.

  • Thrombectomy
  • Stroke
  • Technology

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  • Contributors RC: design of the work, acquisition of data, interpretation of data, drafting of the manuscript. GT: study conception and design, acquisition of data, interpretation of data, critical revision of the manuscript. FH: study conception, interpretation of data, critical revision of manuscript. All authors assisted in interpretation of data and critical revision of manuscript.

  • Competing interests PR is on the scientific advisory board for Medtronic Neurovascular and Stryker Neurovascular.

  • Ethics approval Institutional review board.

  • Provenance and peer review Not commissioned; externally peer reviewed.