Article Text

Download PDFPDF
Variability of results of recent acute endovascular trials: a statistical analysis
  1. Mayank Goyal,
  2. Bijoy K Menon
  1. Department of Radiology and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
  1. Correspondence to Dr Mayank Goyal, Seaman Family MR Research Centre, Foothills Medical Centre, 1403—29th St NW, Calgary, Alberta, Canada T2N 2T9; mgoyal{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Five recent trials have shown the benefit of endovascular treatment in patients with acute ischemic stroke due to large vessel occlusion in the anterior circulation.1–5 There were a lot of commonalities between the trials. The key ones were: most patients had clinically severe ischemic stroke; most patients had small core based on imaging; all patients had neurovascular imaging to detect the presence of proximal vessel occlusion; most patients had an M1±intracranial internal carotid artery occlusion; a stent retriever was used for clot retrieval in the majority of patients.6–8 There were also commonalities in the results: all trials used the modified Rankin Scale (mRS) at 90 days and used shift analysis (EXTEND-IA was a phase IIB study with reperfusion and/or NIH Stroke Scale at 24 h as the primary outcome; however this trial also reported mRS at 90 days as their secondary analysis); all trials showed a statistically significant benefit of endovascular treatment over the control arm. The complication rates (symptomatic intracranial hemorrhage) of endovascular treatment were exceedingly low across all trials.

There were, nonetheless, some differences between these trials. The key differences were: some trials had a lot of focus on speed and workflow (ESCAPE and SWIFT PRIME), some trials used CT perfusion for patient selection (EXTEND-IA and most of the patients …

View Full Text


  • Competing interests BKM was a member of the steering and executive committee of the ESCAPE trial. MG was co-PI of the ESCAPE and SWIFT PRIME trials. MG has a licensing agreement with GE Healthcare for further development of systems of stroke diagnosis.

  • Provenance and peer review Not commissioned; internally peer reviewed.