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E-040 Five-year Single Center Experience of Intracranial Aneurysm Treatment with the PED in Patients of different Age Groups
  1. A Kuhn,
  2. J Lozano,
  3. K de Macedo Rodrigues,
  4. F Massari,
  5. A Wakhloo,
  6. D Rex,
  7. M Gounis,
  8. M Marosfoi,
  9. M Perras,
  10. C Brooks,
  11. M Howk,
  12. A Puri
  1. Division of Neuroimaging and Intervention, Department of Radiology and New England Center for Stroke, University of Massachusetts, Worcester, MA


Purpose To evaluate safety and efficacy of the pipeline embolization device (PED) in patients of different age groups and with incidentally found or recanalised (previously coiled or clipped) aneurysms.

Materials and methods All patients with an incidentally found or recanalised aneurysm and treated with the PED at our institution between 2011 and 2016 were included. We then divided the patient cohort into three age groups representing young (Y, ≤45 years), middle age (M, 46- <65 years) and older (O, ≥65 years) individuals. Information on patient’s vascular risk factors, presenting symptoms and mRS on admission was collected. Follow-up imaging was evaluated for aneurysmal occlusion and the presence of intimal hyperplasia. Patient clinical outcome at discharge, 6 and 12 months was documented.

Results We included 140 patients harboring 164 aneurysms with 20 patients in the young age group, 88 in the middle age and 32 in the older age group. Male to female ratio was approximately 1:4 overall and interestingly in all age groups as well. The majority of aneurysms were located in the anterior circulation (94.5%) and found incidentally (75%). Twenty-four aneurysms had been previously treated (12 ruptured and 12 unruptured). Smoking, hypertension and dyslipidemia were the most frequently encountered vascular risk factors in all age groups, with smoking being most common in the young, hypertension the most common in the middle age and hypertension/dyslipidemia the most common in the older age group. Median mRS on admission and discharge was 0 for all age groups. The median mRS remained 0 at 6 and 12 month follow-up. Overall mortality and morbidity rate was 2.1% (3/140, M = 2 and O = 1), Complete aneurysm occlusion at 6 and 12 months was seen in 77% (78/101) and 80% (52/65), respectively. Mild intimal hyperplasia was seen in 18 cases total (18%) with 2 cases in the young, 11 in the middle age and 5 in the older age group. Moderate and severe intimal hyperplasia was found in one case each (young and older age group). No retreatment was required.

Nine aneurysms (Y = 3, M = 5 and O = 1) which demonstrated near complete occlusion at 6 months showed complete occlusion in 2 cases (M = 2) and stable near complete occlusion in the remaining 7 at the 12 month mark. For aneurysms demonstrating partial occlusion at 6 months (Y = 2, M = 5, O = 3), 12 months follow-up showed progression to complete or near complete occlusion in 1 case each (Y = 1 and M = 1) and stable partial occlusion in 3 cases (M = 3).

Available 12 months follow-up for mild intimal hyperplasia detected at 6 months showed resolution in 4 cases (M = 1 and O = 3) and stable mild hyperplasia in 5 cases (Y = 1 and M = 4). One case of moderate intimal hyperplasia at 6 months (young age group) improved to mild hyperplasia at 12 months follow-up.

Subanalysis of treatment outcome of incidentally found aneurysms compared to unruptured pretreated or ruptured pretreated aneurysms showed no difference of flow diverter performance between the different aneurysm groups or among the different patient age groups.

Conclusion PED placement is feasible and safe in patients of different age groups and with incidental or recanalised aneurysms.

Disclosures A. Kuhn: None. J. Lozano: None. K. de Macedo Rodrigues: None. F. Massari: None. A. Wakhloo: 1; C; NIH, Philips Healthcare, Wyss Institute. 2; C; Codman Neurovascular and Stryker Neurovascular. 3; C; Harvard Postgraduate Course, Miami Cardiovascular Institute. 4; C; InNeuroCo Inc, EpiEB and Pulsar Medical. D. Rex: None. M. Gounis: 1; C; NIH, Medtronic Neurovascular, Microvention/Terumo, Cerevasc LLC, Gentuity, Codman Neurovascular, Philips Healthcare, Stryker Neurovascular, Tay Sachs Foundation, and InNeuroCo Inc. 2; C; Codman Neurovascular and Stryker Neurovascular. 4; C; InNeuroCo Inc. M. Marosfoi: None. M. Perras: None. C. Brooks:None. M. Howk: None. A. Puri: 1; C; Stryker Neurovascular and Covidien. 2; C; Codman Neurovascular, Stryker Neurovascular and Covidien. 3; C; Miami Cardiovascular Institute. 4; C; InNeuroCo Inc.

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