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E-071 Initial Experimental Result of a Novel, Low Profile Stent for Aneurysm Treatment
  1. I Kan,
  2. Y Murayama,
  3. K Karagiozov,
  4. A Ikemura,
  5. I Yuki,
  6. H Takao,
  7. T Kodama
  1. Neurosurgery, The Jikei University School of Medicine, Tokyo, Japan


Introduction Stent assisted coil therapy has been developed for treatment of wide neck aneurysms. However, several reports show that recanalization rate of 10–15% after therapy is still observed. A novel low profile, flow diverter stent has been developed, and initial experience with it in an experimental wide-neck aneurysm swine model is reported.

Method The novel stent is self-expandable with radiopaque markers on both ends and 0.023 inch inner size compatible microcatheter. Eighteen aneurysms in 9 swine were surgically created using vein auto-grafts. Embolizations were performed in following device combinations: Novel Stent with coil (Group1: Novel stent, n = 6), commercially available stent (Group2: Neuroform stent, n = 6) with coil, and coil alone (Group3: coil, n = 6). Swine were sacrificed 14 days after stent deployment.

Results Mean aneurysm neck size was 6.24 mm (4.3–8.26 mm), and average aneurysm fundus size was 9.0 mm (5.8–10.9 mm). All cases in Group2 were treated by Neuroform stent. Average VER (volume embolization ratio) of Group1, Group2, and Group3 was 10.1%, 10.9%, and 10.5%, respectively. There were no technical complications during novel stent deployment, such as migration, occlusion, etc. Favorable angiographic outcome, such as complete aneurysm thrombosis, was observed in 50% of group3, and there was no favorable outcome in both group2 and 3. Recanalization rate of group1, 2, and 3 is 50% (n = 3), 100% (n = 6), and 66% (n = 4), respectively. Aneurysmal rupture after procedure was observed in three cases from group 2, and two cases from group 3.

Conclusion The present study showed promising initial experience with the novel stent, particularly for its role as a low profile flow diverting stent and as an assisting stent for coil therapy.

Disclosures I. Kan: 1; C; Japan Agency for Medical Research and Development. Y. Murayama: 1; C; Japan Agency for Medical Research and Development. K. Karagiozov: None. A. Ikemura: None. I. Yuki: None. H. Takao: None. T. Kodama: None.

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