Background and purpose Diffusion (DWI) change area regard as cytotoxic edema and ischemic core. And perfusion/diffusion mismatching (P/D-mismatch) is regard as ischemic penumbra and targeted tissue to ischemic stroke treatment. Exact diffusion volume may be important to speculate the patient prognosis. But there were no studies which compare the clinical significance of the diffusion volume and P/D-mismatch.

Materials and methods 57 patients whom treated additional IA-Tx, non-recanalised after IV-tPA with anterior circulation and major vessel occlusion, were analyzed retrospectively. Diffusion volume was calculated from MR graphic program and P/D-mismatch was evaluated by radiologist who was not involved in patient treatment. Statistical analysis were done according to the DWI volume and P/D-mismatch, in recanalization, favorable outcome, and significant hemorrhage.

Results P/D-mismatch was statistical significant prospect on favorable outcome (χ², p = 0.000), neuroloic improvement(χ², p = 0.000), significant hemorrhage (χ², p = 0.043), extravascation (χ², p = 0.000) and decompressive surgical incidence (χ², p = 0.007). But diffusion volume, evaluated cording to 30 cc, 60 cc, 100 cc grading analysis, not predict neurologic outcomes, hemorrhagic complications.

Conclusion In this study, diffusion volume calculation is impossible to calculate without computerized program and clinical significance of diffusion volume was questionable. P/D-mismatch was more significant prognostic indicator than diffusion volume in acute stroke patients management.

Disclosures Y. Won: None. D. Yoo: None. T. Won: None. S. Lee: None.