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Original research
Treatment of wide-necked aneurysms with the Low-profile Visualized Intraluminal Support (LVIS Jr) device: a multicenter experience
  1. J A Grossberg1,
  2. R A Hanel2,
  3. G Dabus3,
  4. K Keigher4,
  5. D C Haussen1,
  6. E Sauvageau2,
  7. I Linfante3,
  8. D Gonsales2,
  9. P Aguilar Salinas2,
  10. M Bouslama1,
  11. M Mayich3,
  12. R G Nogueira1,
  13. D K Lopes4
  1. 1 Emory University/Grady Memorial Hospital, Atlanta, Georgia, USA
  2. 2 Baptist Neurological Institute, Jacksonville, Florida, USA
  3. 3 Department of NeuroInterventional Surgery, Miami Cardiac & Vascular Institute and Baptist Neuroscience Center, Miami, Florida, USA
  4. 4 Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois, USA
  1. Correspondence to Dr Jonathan A Grossberg, 49 Jesse Hill Jr Drive SE, Room 337, Atlanta, GA 30303, USA; Jonathan.A.Grossberg{at}


Background The Low-profile Visualized Intraluminal Support (LVIS) Junior stent is newly approved for the treatment of wide-necked intracranial aneurysms.

Objective To report our multicenter experience with use of the LVIS Jr device.

Methods The neurointerventional databases of the participating institutions were retrospectively reviewed for aneurysms treated with LVIS Jr from the time of Food and Drug Administration approval until February 2016. All patients in the study period were included. Clinical presentation, aneurysm location, aneurysm size, vessel size, procedural complications, clinical and imaging follow-up were included in the analysis.

Results Eighty-five patients (54 female and 31 male) met the inclusion criteria for the study. Sixty-eight (80%) of the aneurysms were unruptured and the remainder were ruptured. The most common location of the treated aneurysms was anterior communicating artery (36%), middle cerebral artery bifurcation (22%), and basilar terminus (15%). The mean aneurysm size was 6.1 mm. The mean minimum parent vessel size was 2.3 mm. The LVIS Jr was successfully deployed in all but one case (99%). Initial angiographic results demonstrated Roy–Raymond class 1–2 occlusions in 61/84 patients (73%). At 6 months, 85% of the patients seen at follow-up had Roy–Raymond class 1–2 aneurysm occlusion. No procedure-related deaths occurred. Two cases of procedure-related complications (intraprocedural rupture and delayed rupture at day 2) were seen, leading to permanent neurologic morbidity. Both these cases were in patients with ruptured aneurysms.

Conclusions The LVIS Jr is a technically feasible, safe, and effective treatment for wide-necked intracranial aneurysms. Early results are promising but will need to be corroborated with longer-term follow-up.

  • Aneurysm
  • Coil
  • Stent

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  • Contributors JAG conducted literature searches, collected data, drafted the initial version of paper, and revised later additions. RAH/GD/KK/DCH/ES/IL/DG/MB/PAS/MM/DKL collected data and revised later versions of the paper. RGN provided the initial idea for the study, collected data, and revised later versions of the paper.

  • Competing interests GD: consultant MicroVention. RAH: consultant, unrestricted educational grant MicroVention. DKL: research grant, advisory board and speaker MicroVention.

  • Ethics approval Institutional review board for each site. Emory/Grady for corresponding author.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional unpublished data are available.