You are here

Article Text

Article menu
Download PDFPDF
Hemorrhagic stroke
Original research
Larger size ratio associated with the rupture of very small (≤3 mm) anterior communicating artery aneurysms
  1. Ting Xu1,
  2. Boli Lin1,
  3. Shuailiang Liu1,
  4. Xiaotong Shao1,
  5. Nengzhi Xia1,
  6. Yue Zhang1,
  7. Haoli Xu1,
  8. Yunjun Yang1,
  9. Ming Zhong2,
  10. Qichuan Zhuge2,
  11. Bing Zhao2,3,
  12. Weijian Chen1
  1. 1Department of Radiology, The first affiliated hospital of Wenzhou Medical University, Wenzhou, China
  2. 2Department of Neurosurgery, The first affiliated hospital of Wenzhou Medical University, Wenzhou, China
  3. 3Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr Weijian Chen, Department of Radiology, or Dr Bing Zhao, Department of Neurosurgery, The first affiliated Hospital of Wenzhou Medical University, Nanbai Xiang Town, Wenzhou 325000, China; wyyycwj{at}163.com, drzhaobing{at}yahoo.com

Abstract

Background Anterior communicating artery (AcoA) aneurysms have a high rupture risk, and ruptured AcoA aneurysms tend to be smaller than other intracranial aneurysms. We aimed to determine the incidence and morphologic predictors of aneurysm rupture of very small AcoA aneurysms.

Methods We conducted a retrospective analysis of 519 consecutive patients with single AcoA aneurysms between December 2007 and February 2015 in our hospital. Aneurysm morphologies were re-measured using CT angiography images. Very small aneurysms were defined as those with a maximum size ≤3 mm, and small aneurysms were defined as those with a maximum size ≤5 mm. Multivariate regression analyses were used to determine the association between aneurysm morphology and aneurysm rupture status.

Results Of the 474 ruptured AcoA aneurysms, 134 (28.3%) aneurysms were very small and 278 (58.6%) aneurysms were small. In the univariate analysis for very small aneurysms, larger aneurysm size (p=0.037), larger size ratio (p=0.002), higher aneurysm height (p=0.038), smaller vessel size (p=0.012), and dominant A1 segment configuration (p=0.011) were associated with aneurysm rupture. Multivariate analysis revealed that a larger size ratio was independently associated with the rupture status of the very small aneurysms (OR 3.69, 95% CI 1.5 to 9.0; p=0.004), and larger aneurysm size, larger size ratio, and dominant A1 segment configuration were associated with the rupture of small aneurysms.

Conclusions About one-third of ruptured AcoA aneurysms were very small. A larger size ratio, rather than other aneurysm morphologies, was independently associated with the rupture of very small AcoA aneurysms.

  • Aneurysm
  • CT Angiography

https://doi.org/10.1136/neurintsurg-2016-012294

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors TX, BL, SL, XS, NX, YZ, and HX were involved in data measurement, collection and verification. BZ was involved in data analysis. YY, MZ, QZ, BZ, and WC were involved in data implementation. TX drafted the manuscript. YY, BZ, and WC critically revised the manuscript. BZ and WC had the idea for the study and protocol design. All authors read and approved the final manuscript.

    • Funding This study was supported by Zhenjiang Provincial Key Laboratory of Aging and Neurological Disorder Research, the Ministry of Science and Technology of China (grant 2012E10008; 2011-BAI08B06), and Wenzhou Bureau of Science and Technology (grant Y20140041).

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval The study was approved by the Institutional Review Board of the first affiliated hospital of Wenzhou Medical University.

    • Provenance and peer review Not commissioned; externally peer reviewed.