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Original research
Weekend effect in endovascular stroke treatment: do treatment decisions, procedural times, and outcome depend on time of admission?
  1. Omid Nikoubashman1,2,
  2. Thomas Probst1,
  3. Kolja Schürmann3,
  4. Ahmed E Othman4,
  5. Oliver Matz2,
  6. Marc-Alexander Brockmann1,
  7. Marguerite Müller1,
  8. Martin Wiesmann1,
  9. Arno Reich3
  1. 1Department of Neuroradiology, University Hospital Aachen, Aachen, Germany
  2. 2Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany
  3. 3Department of Neurology, University Hospital Aachen, Aachen, Germany
  4. 4Department of Radiology, University Hospital Tübingen, Tübingen, Germany
  1. Correspondence to Dr Omid Nikoubashman, Klinik für Neuroradiologie, Uniklinikum Aachen, Pauwelsstr 30, Aachen 52074, Germany; onikoubashman{at}


Background Epidemiologic studies identified a ‘weekend effect’ or ‘out-of-hours effect’, which implies that procedural and clinical outcomes of patients with stroke, who are admitted out-of-hours, are less favorable than for patients admitted during working-hours.

Objective To determine (1) whether our procedural times and clinical outcome were affected by an out-of-hours effect and (2) whether the decision in favor of, or against, endovascular stroke treatment (EST) depends on the time of admission.

Methods Between February 2010 and January 2015, 6412 consecutive patients presenting with symptoms of acute ischemic stroke were evaluated for EST eligibility according to established local protocols and generally accepted consensus criteria, and dichotomized into working-hours and out-of-hours cohorts according to admission times. Within both groups, patients given EST were identified and the rate of treatment decision, procedural times, and clinical outcome were compared and analyzed.

Results Clinical and radiological features of patients admitted in working-hours and out-of-hours did not differ significantly. Procedural times and clinical outcome were not affected by an out-of-hours effect (p≥0.054). 221/240 (92.1%) out-of-hours patients and 154/166 (92.8%) working-hours patients who were eligible for EST were transferred to the angiography suite for EST (p=0.798). The rationale not to treat patients who were eligible for EST did not differ between working-hours and out-of-hours admission (p=0.756).

Conclusions It is possible to produce competitive procedural times regardless of the time of admission and to prevent a treatment decision bias when standard operating procedures are applied consistently.

  • Intervention
  • Angiography
  • Atherosclerosis
  • Stent
  • Stroke

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  • ON and TP contributed equally.

  • Correction notice This article has been corrected since it published Online First. The contributors statement has been updated.

  • Contributors : All authors: conception and design; acquisition of data; analysis and interpretation of data; critical revision of the article. TP: drafting the article.

  • Competing interests M-AB: non-financial support from Covidien, Stryker, Terumo/Microvention. MW: grants from Stryker Neurovascular, Siemens Healthcare; personal fees from Stryker Neurovascular, Silkroad Medical, Siemens Healthcare, Bracco; non-financial support from Codman Neurovascular, Covidien, Abbott, St Jude Medical, Phenox, Penumbra, Microvention/Terumo, B Braun, Bayer, Acandis, ab medica.

  • Ethics approval RWTH University Aachen, Germany.

  • Provenance and peer review Not commissioned; externally peer reviewed.