Article Text

PDF
Original research
Antiplatelet pretreatment and outcomes following mechanical thrombectomy for emergent large vessel occlusion strokes
  1. Abhi Pandhi1,
  2. Georgios Tsivgoulis1,2,
  3. Rashi Krishnan1,
  4. Muhammad F Ishfaq1,
  5. Savdeep Singh1,
  6. Daniel Hoit3,
  7. Adam S Arthur3,
  8. Christopher Nickele3,
  9. Andrei Alexandrov1,
  10. Lucas Elijovich1,3,
  11. Nitin Goyal1
  1. 1Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
  2. 2Second Department of Neurology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece
  3. 3Department of Neurosurgery, University of Tennessee Health Science Center, Semmes-Murphey Neurologic and Spine Clinic, Memphis, Tennessee, USA
  1. Correspondence to Dr Nitin Goyal, Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA; ngoyal{at}uthsc.edu

Abstract

Background Few data are available regarding the safety and efficacy of antiplatelet (APT) pretreatment in acute ischemic stroke (AIS) patients with emergent large vessel occlusions (ELVO) treated with mechanical thrombectomy (MT). We sought to evaluate the association of APT pretreatment with safety and efficacy outcomes following MT for ELVO.

Methods Consecutive ELVO patients treated with MT during a 4-year period in a tertiary stroke center were evaluated. The following outcomes were documented using standard definitions: symptomatic intracranial hemorrhage (sICH), successful recanalization (SR; modified TICI score 2b/3), mortality, and functional independence (modified Rankin Scale scores of 0–2).

Results The study population included 217 patients with ELVO (mean age 62±14 years, 50% men, median NIH Stroke Scale score 16). APT pretreatment was documented in 71 cases (33%). Patients with APT pretreatment had higher SR rates (77% vs 61%; P=0.013). The two groups did not differ in terms of sICH (6% vs 7%), 3-month mortality (25% vs 26%), and 3-month functional independence (50% vs 48%). Pretreatment with APT was independently associated with increased likelihood of SR (OR 2.18, 95% CI1.01 to 4.73; P=0.048) on multivariable logistic regression models adjusting for potential confounders. A significant interaction (P=0.014) of intravenous thrombolysis (IVT) pretreatment on the association of pre-hospital antiplatelet use with SR was detected. APT pretreatment was associated with SR (OR 2.74, 95% CI 1.15 to 6.54; P=0.024) in patients treated with combination therapy (IVT and MT) but not in those treated with direct MT (OR 1.78, 95% CI 0.63 to 5.03; P=0.276).

Conclusion APT pretreatment does not increase the risk of sICH and may independently improve the odds of SR in patients with ELVO treated with MT. The former association appears to be modified by IVT.

  • stroke
  • thrombectomy

Statistics from Altmetric.com

Footnotes

  • A portion of this study’s findings has been presented at the Society of Neurointerventional Surgery Annual Meeting, 2016.

  • Contributors AP: Study concept and design, acquisition of data, analysis and interpretation, and critical revision of the manuscript for important intellectual content. GT: Analysis and interpretation and critical revision of the manuscript for important intellectual content. RK, MFI: Acquisition of data and critical revision of the manuscript for important intellectual content. SS, DH, ASA, CN, AA, LE: Critical revision of the manuscript for important intellectual content. NG: Study concept and design, acquisition of data, critical revision of the manuscript for important intellectual content, study supervision.

  • Competing interests None declared.

  • Ethics approval University of Tennessee IRB.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.