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Original research
Endovascular thrombectomy beyond 12 hours of stroke onset: a stroke network’s experience of late intervention
  1. Ronan Motyer1,2,
  2. John Thornton1,
  3. Sarah Power1,
  4. Paul Brennan1,
  5. Alan O’Hare1,
  6. Seamus Looby1,
  7. David J Williams3,4,
  8. Barry Moynihan4,
  9. Sean Murphy5,6,7
  1. 1Interventional Neuroradiology Service, Department of Radiology, Beaumont Hospital, Dublin, Ireland
  2. 2Department of Radiology, The Adelaide and Meath Hospital, Dublin, Ireland
  3. 3Department of Geriatric and Stroke Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
  4. 4Department of Geriatric and Stroke Medicine, Beaumont Hospital, Dublin, Ireland
  5. 5Department of Geriatric and Stroke Medicine, The Mater Misericordiae University Hospital, Dublin, Ireland
  6. 6School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
  7. 7School of Medicine, University College Dublin, Dublin, Ireland
  1. Correspondence to Dr Ronan Motyer, Department of Radiology, Beaumont Hospital, Dublin 9, Ireland; ronanmotyer{at}gmail.com

Abstract

Background Selected patients with proximal anterior circulation ischemic stroke who demonstrate limited infarct and sufficient penumbra may benefit from endovascular thrombectomy (EVT) beyond conventional time limits.

Objective To perform a retrospective review of all cases of EVT performed at our institution for proximal anterior circulation acute ischemic stroke with onset >12 hours.

Materials and methods Patients were assessed with non-contrast CT brain and multiphase CT angiography, with Alberta Stroke Program Early CT Score (ASPECTS) and collateral grade informing patient selection. Data, including patient demographics, workflow, neuroimaging findings, procedural details, recanalization rates, and 90-day functional outcomes, were collected.

Results Of the 542 consecutive endovascular thrombectomy cases performed during the study period, 25 (4.6%) were >12 hours from stroke onset. Median age was 69 years (IQR 55–80), median National Institute of Health Stroke Scale score on presentation was 14 (IQR 11–18.5), median ASPECTS was 8 (IQR 8–9), and rate of moderate–good collateral status was 96% (n=24). Median time to groin puncture was 14 hours 40 min (IQR 12 hours 36 min – 16 hours 18 min). Rate of successful recanalization (modified Thrombolysis in Cerebral infarction 2b–3) was 88% (n=22). Rate of functional independence (90-day modified Rankin Scale score 0–2) was 52% (n=13). There were no cases of symptomatic intracranial haemorrhage and 90-day mortality rate was 12% (n=3).

Conclusion With the use of ASPECTS and collateral grade to guide patient selection, good functional outcome with acceptable safety parameters may be achieved in patients undergoing EVT beyond 12 hours from stroke onset.

  • endovascular
  • stroke
  • large vessel occlusion
  • thrombectomy
  • thrombolysis
  • recanalization
  • IV tPA

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Footnotes

  • Contributors RM is lead author, monitored data collection, interpreted and presented acquired data, drafted and revised the manuscript, approved submitted version and agrees to be accountable for all aspects of the work. JT is senior author, implemented and directed service, designed data collection tools, acquired data, monitored data collection, interpreted data, advised and revised the manuscript, approved submitted version and agrees to be accountable for all aspects of the work. SP, PB AOH, SL, DJW, BM implemented the service, designed data collection tools, acquired data, monitored data collection, interpreted data, advised and revised the manuscript, approved submitted version and agree to be accountable for all aspects of the work. SM is senior author, advised on service implementation, monitored data collection, interpreted data, advised and revised the manuscript, approved submitted version and agrees to be accountable for all aspects of the work.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval Beaumont Hospital Quality and Standards Department.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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