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New Devices
Original research
Novel aspiration catheter design for acute stroke thrombectomy
  1. Troy D Long1,
  2. David F Kallmes2,
  3. Ricardo Hanel3,
  4. Tomoyoshi Shigematsu4,
  5. Alexander Michael Halaszyn5,
  6. Julia Wolter5,
  7. Alejandro Berenstein4
  1. 1 North Memorial Medical Center, Robbinsdale, Minnesota, USA
  2. 2 Mayo Clinic, Rochester, Minnesota, USA
  3. 3 Baptist Health, Jacksonville, Florida, USA
  4. 4 Mount Sinai Health System, New York City, New York, USA
  5. 5 University of Minnesota, Minneapolis, Minnesota, USA
  1. Correspondence to Dr Troy D Long, North Memorial Medical Center, Robbinsdale, MN 55422, USA; tlong{at}mplsrad.com

Abstract

Background Navigable, large diameter aspiration catheters demonstrate markedly improved recanalization rates over smaller lumen devices in suction embolectomy. We evaluated the performance of a novel aspiration catheter system designed to maximize lumen size, and compare it to other commercially available aspiration catheters.

Methods The 6F R4Q aspiration catheter system comprises a proximal pusher wire of 117 cm length connected to a distal catheter of 25 cm length. When placed through standard guide catheters and into the cerebral circulation, the proximal catheter makes a tight seal between its outer surface and the guide catheter’s inner surface. During aspiration, in vitro flow rates and tip suction force under gentle retraction were compared among 10 commercially available aspiration catheters and the R4Q system.

Results The R4Q 6F, 5F, 4F, and 3F catheters achieved flow rates at least 21.9%, 24.7%, 61.9%, and 244.7% greater than the other catheters tested respectively and the R4Q 6F produced a 140.2% higher tip force than a catheter of similar size. Fluid flow rate in the R4Q 6F increased on retraction into the guide catheter, delivering a 58.2% increase from fully extended to fully retracted.

Conclusion The R4Q design demonstrates a substantial increase in aspirated flow rate and suction force due to an increased effective diameter than standard tubular catheter designs tested. The prominent increase in the aspiration parameters measured in vitro supports the potential for improved clinical results during stroke thrombectomy procedures.

  • brain
  • catheter
  • device
  • stroke
  • thrombectomy

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/neurintsurg-2017-013702

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    Footnotes

    • Contributors TDL, TS, AB, AMH, and DFK conceived of the presented idea and study design. AMH and JW collected and analyzed the data and drafted the manuscript. All authors reviewed the manuscript and delivered substantial feedback. Throughout the entire process, all authors provided critical input for planning, implementing, and presenting the study.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial, or not-for-profit sectors.

    • Competing interests DFK reports other from Marblehead Medical, grants from CURAM, outside the submitted work; In addition, DFK has a patent Balloon Guiding System pending. RH reports personal fees from MIVI Neuroscience, Inc., outside the submitted work. AMH reports grants from MIVI Neuroscience Inc., during the conduct of the study; In addition, AMH has a patent 14/949,574 pending to Mivi Neuroscience Inc. JW reports personal fees from MIVI Neuroscience, Inc., outside the submitted work. AB reports grants and personal fees from MICROVENTION, personal fees from MIVI NEUROSCIENCE, personal fees from SCIENTIA VASCULAR, personal fees from ENDOSTREAM MEDICAL, personal fees from BENDIT TECHNOLOGIES, personal fees from MAGNETO THROMBECTOMY SOLUTIONS, and personal fees from ANGIODYNAMICS, outside the submitted work.

    • Patient consent Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.