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Original research
Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept
  1. Jildaz Caroff1,
  2. Robert M King2,4,
  3. Jennifer E Mitchell3,
  4. Miklos Marosfoi2,
  5. Joseph R Licwinko3,
  6. Heather L Gray-Edwards2,
  7. Ajit S Puri2,
  8. Thomas L Merrill3,5,
  9. Matthew J Gounis2
  1. 1Interventional Neuroradiology, NEURI Center, Bicêtre Hospital, Le Kremlin- Bicêtre, France
  2. 2New England Center for Stroke Research, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
  3. 3FocalCool, Mullica Hill, New Jersey, USA
  4. 4Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA
  5. 5Department of Mechanical Engineering, Rowan University, Glassboro, NJ, USA
  1. Correspondence to Dr Matthew J Gounis, Department of Radiology, University of Massachusetts, Worcester MA 1655, USA; matthew.gounis{at}umassmed.edu

Footnotes

  • Contributors All authors: designed and performed the experiments, analysed the data, drafted the manuscript, and approved the final manuscript.

  • Funding This research was funded by NIH 1 R43 NS095573-01A1 (PI: TLM). JC was supported by research grants from the Fulbright Program, the Philippe Foundation, and the French Society of Radiology (SFR-CERF). The content is solely the responsibility of the authors and does not reflect the opinions of the sponsors.

  • Competing interests RMK declares no competing interest. JC: has received educational scholarships from Medtronic Neurovascular and Microvention/Terumo. MM: Fee-for-service consulting for Stryker Neurovascular and InNeuroCo. JEM, JRL. and TLM: are employees of FocalCool. ASP: consultant for Medtronic Neurovascular and Stryker Neurovascular; research grants from Medtronic Neurovascular and Stryker Neurovascular. MJG: has been a consultant on a fee-per-hour basis for Cerenovus, Imperative Care, Mivi Neurosciences, Phenox, Route 92 Medical, Stryker Neurovascular; holds stock in Imperative Care and Neurogami; and has received research support from the National Institutes of Health (NIH), USA–Israel Binational Science Foundation, Anaconda, Cerenovus, Cook Medical, Gentuity, Imperative Care, InNeuroCo, Magneto, Microvention, Medtronic Neurovascular, MIVI Neurosciences, Neuravi, Neurogami, Philips Healthcare, Rapid Medical, Route 92 Medical, Stryker Neurovascular, Syntheon, and the Wyss Institute.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data presented in the manuscript.

  • Patient consent for publication Not required.

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Footnotes

  • Contributors All authors: designed and performed the experiments, analysed the data, drafted the manuscript, and approved the final manuscript.

  • Funding This research was funded by NIH 1 R43 NS095573-01A1 (PI: TLM). JC was supported by research grants from the Fulbright Program, the Philippe Foundation, and the French Society of Radiology (SFR-CERF). The content is solely the responsibility of the authors and does not reflect the opinions of the sponsors.

  • Competing interests RMK declares no competing interest. JC: has received educational scholarships from Medtronic Neurovascular and Microvention/Terumo. MM: Fee-for-service consulting for Stryker Neurovascular and InNeuroCo. JEM, JRL. and TLM: are employees of FocalCool. ASP: consultant for Medtronic Neurovascular and Stryker Neurovascular; research grants from Medtronic Neurovascular and Stryker Neurovascular. MJG: has been a consultant on a fee-per-hour basis for Cerenovus, Imperative Care, Mivi Neurosciences, Phenox, Route 92 Medical, Stryker Neurovascular; holds stock in Imperative Care and Neurogami; and has received research support from the National Institutes of Health (NIH), USA–Israel Binational Science Foundation, Anaconda, Cerenovus, Cook Medical, Gentuity, Imperative Care, InNeuroCo, Magneto, Microvention, Medtronic Neurovascular, MIVI Neurosciences, Neuravi, Neurogami, Philips Healthcare, Rapid Medical, Route 92 Medical, Stryker Neurovascular, Syntheon, and the Wyss Institute.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data presented in the manuscript.

  • Patient consent for publication Not required.

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