Article Text

Download PDFPDF

Transradial approach for neurointerventions: a systematic review of the literature
  1. Krishna C Joshi,
  2. André Beer-Furlan,
  3. R Webster Crowley,
  4. Michael Chen,
  5. Stephan A Munich
  1. Neurological Surgery, Rush University Medical Center, Chicago, Illinois, USA
  1. Correspondence to Dr Krishna C Joshi, Neurological Surgery, Rush University Medical Center, Chicago, IL 60612, USA; Krishna_C_Joshi{at}


Background Despite the recent increase in the number of publications on diagnostic cerebral angiograms using transradial access (TRA), there have been relatively few regarding TRA for neurointerventional cases. Questions of feasibility and safety may still exist among physicians considering TRA for neurointerventional procedures.

Methods A systematic literature review was performed following PRISMA guidelines. Three online databases (MedLine via PubMed, Scopus and Embase) were searched for articles published between January 2000 and December 2019. Search terms included “Transradial access”, “Radial Access”, “Radial artery” AND “Neurointerventions". The reference lists of selected articles and pertinent available non-systematic analysis were reviewed for other potential citations. Primary outcomes measured were access site complications and crossover rates.

Results Twenty-one studies (n=1342 patients) were included in this review. Two of the studies were prospective while the remaining 19 were retrospective. Six studies (n=616 patients) included TRA carotid stenting only. The rest of the studies included treatment for cerebral aneurysms (n=423), mechanical thrombectomy (n=127), tumor embolization (n=22), and other indications (n=154) such as angioplasty and stenting for vertebrobasilar stenosis, balloon test occlusion, embolization of dural arteriovenous fistula and arteriovenous malformation, chemotherapeutic drug delivery, intra-arterial thrombolysis, and arterial access during a venous stenting procedure. Two (0.15%) major complications and 37 (2.75%) minor complications were reported. Sixty-four (4.77%) patients crossed over to transfemoral access for completion of the procedure. Seven (0.52%) patients crossed over due to access failure and 57 (4.24%) patients crossed over to TFA due to inability to cannulate the target vessel.

Conclusion This systematic review demonstrates that TRA has a relatively low rate of access site complications and crossovers. With increasing familiarity, development of TRA-specific neuroendovascular devices, and the continued reports of its success in the literature, TRA is expected to become more widely used by neurointerventionalists.

  • complication
  • device
  • intervention
  • technique
  • angiography

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:

View Full Text

Statistics from


Transradial access (TRA) has several distinct advantages over traditional transfemoral access (TFA). More than 10 years of experience reported by interventional cardiologists has demonstrated a reduction in the incidence of hemorrhagic access site complications with TRA compared with TFA.1–3 When hemorrhagic events arise, they are typically more easily managed given the radial artery’s superficial location and ease of compressibility. Additionally, post-procedure bedrest is not required, facilitating early ambulation and discharge following procedures not requiring hospital admission.4–6

Despite the widespread adoption and preference of TRA among cardiac interventionalists, neurointerventionalists have been slow to adopt this approach. There are 24 randomized controlled trials comparing TRA with TFA in the cardiac intervention literature compared with none in neurointervention. The overall superiority of TRA over TFA, especially in terms of access site complications, suggests that TRA for neurointervention should be explored in greater detail. We therefore sought to perform a systematic review to summarize the feasibility, complications, and crossover rates of TRA in various neurointerventional procedures.

Materials and methods

Data sources and searches

Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed and the protocol was submitted to PROSPERO. Three online databases (MedLine via PubMed, Scopus and Embase) were searched using filters for English language articles published between 1 January 2000 and 31 December 2019. Medical subject headings and keyword searches included the terms “Transradial access”, “Radial Access”, “Radial Artery” AND “Neurointerventions”. In addition, the reference lists of selected articles and pertinent available non-systematic analysis were reviewed for other potential citations. Data from unpublished sources were not searched or included.

Study selection and data extraction

Two investigators (KCJ and ABF) conducted independent literature searches and data extractions using a standardized approach. Selected publications on TRA for neurointervention were reviewed by the same investigators to assess if the studies met the inclusion criteria: (1) studies with ≥5 patients; (2) studies involving any kind of neurointerventions including (but not limited to) aneurysm coiling, thrombectomies for acute ischemic stroke, and carotid artery stent (CAS). Studies which were (1) technical reports and case reports, (2) series with only diagnostic angiograms, and (3) cadaver and animal series were excluded. Studies with only distal radial access (dTRA), left radial access, or those describing repeat radial access were excluded. Two reviewers (KCJ and ABF) extracted information from articles including year of publication, indications for procedure, sample size, complications related to access, and crossover rates.

Data analysis and synthesis

Demographic and procedural data were analyzed from these papers and a systematic analysis was performed. Primary outcomes analyzed were complication rates, crossover to transfemoral rate, and procedural success rates. Secondary outcomes were to measure the procedural success rate with relation to the indications. Technical nuances with regard to indications, techniques used to improve puncture and access, size and characteristics of devices used, techniques used for hemostasis, and device selection for particular indications were noted. Heterogeneity testing was performed using Cochrane Q statistics to calculate I2 percentages; ≥50% would indicate statistically significant heterogeneity. Bias risk assessment was assessed using funnel plots.


Search results

The initial search collectively resulted in 90 papers, of which 45 came from the MeSH PubMed search, 38 from Scopus and 7 from Embase, and an additional 15 articles came from a bibliographic search of the other articles. After removing duplicates, 74 studies remained. Through title and abstract review we narrowed the search to 37 articles and excluded 37 articles, which were assessed using the previously mentioned selection criteria. An additional 16 articles were excluded after full text review resulting in 21 articles that fit our inclusion standards. Of note, one patient who underwent arterial access using TRA for a case of venous stenting was included due to its inclusion in the source studies. The results of our literature screening are summarized in figure 1.

Figure 1

PRISMA diagram summarizing the systematic process used to identify, screen, and include articles analyzed for this review.

Included studies

Twenty-one studies (n=1342) were included in this review. Baseline demographics were described in 14 studies (n=742), the median age was 66.21 years (range 48.5–86 years), and 315 (42.40%) were women. Six studies (616 patients) included TRA for CAS only. The remaining studies (n=726) included a variety of other neurointerventional procedures conducted through TRA. There were 423 aneurysms treated with TRA. Two studies (n=57) included patients treated with flow diverters (FD) for unruptured aneurysms. One hundred and twenty-seven patients were treated for acute ischemic stroke with mechanical thrombectomy (MT). The remaining cases included tumor embolization (n=22), treatment of vasospasm (n=26), angioplasty and stenting for vertebrobasilar stenosis (n=69), intracranial carotid angioplasty (n=4), balloon test occlusion (n=8), embolization of dural arteriovenous fistula (n=4), embolization of arteriovenous malformation (n=24), chemotherapeutic drug delivery (n=10), thrombolysis (n=5), vertebral artery sacrifice (n=1), middle meningeal artery embolization (n=2), and arterial access during a venous stenting procedure (n=1). Figure 2 shows the distribution of various indications of neurointerventional procedures performed by TRA. The side of lesion was mentioned in 692 cases: 391 (56.50%) interventions were performed on the right side, 300 (43.35%) were performed on the left side, and one was bilateral (0.14%). The location of the lesion was described as an anterior or posterior circulation lesion in 955 cases, of which 816 (85.44%) were located in the anterior circulation and 121 (14.55%) were located in the posterior circulation. The studies included are described in table 1.7–27

Figure 2

Pie chart demonstrating the various indications for neurointervention using the transradial access.

Table 1

Brief description of the design and results of 21 eligible studies included in the systematic analysis

The Cochrane I2 test revealed no significant heterogeneity in studies reporting major complications (I2=20.7%); however, there was significant heterogeneity in studies reporting minor complications (I2=79.8%) and crossovers (I2=62.5%). Publication bias could not be calculated as there was significant heterogeneity in reported outcomes and no statistical effect size in most of the studies.


The studies were reviewed for access site complications, which were classified into minor (asymptomatic and found on routine follow-up or minimally symptomatic, which did not require readmission and intervention) and major (which were symptomatic and required further intervention such as blood transfusion or surgical intervention).

Two (0.15%) major complications were reported: one patient with Buerger’s disease had an acute symptomatic radial artery occlusion (RAO) and one patient had a large hematoma requiring blood transfusion.

There were 37 (2.75%) minor complications reported. Among the minor complication group, asymptomatic RAO was detected either clinically (through the absence of a palpable pulse) or on doppler in follow-up in 27 (72.97%) patients, severe radial artery spasm and pain in 4 (10.81 %) patients, and small forearm hematoma in 6 (16.21%) patients.


Sixty-four (4.77%) patients crossed over to TFA for completion of the procedure. Among the crossover group, seven (10.93%) patients crossed over due to failure to obtain radial artery access. In all of these cases intractable severe radial artery spasm was noted. Fifty-seven (89.06%) patients crossed over to TFA due to inability to catheterize the target vessel. The anatomical constraints impeding catherization of the target vessel were mentioned in 13 cases in which crossover to TFA was necessary; in eight cases aortic arch configuration precluded catheterization and in five cases acute angulation of the origin of the internal carotid artery (ICA) from the arch was noted. The results of the review are shown in table 2.

Table 2

Results from systematic analysis of 21 studies on transradial approach for neurointervention


Our results

There is extensive evidence in the interventional cardiology literature supporting the safety and efficacy of TRA over TFA.1–3 Only recently has TRA begun to be increasingly considered as a reasonable alternative to the more familiar TFA among neuroendovascular surgeons. However, its utility often has been mostly restricted to diagnostic cerebral angiography.28–30 Potential concerns with TRA for neurointerventional procedures include lack of familiarity, concern for placing larger access catheters in the radial artery, and a lack of devices with dimensions and specifications designed specifically for TRA.

We performed a systematic review of the literature on the use of TRA for various neurointerventional procedures. We found a total of 21 articles that qualified for our inclusion criteria and a total of 1342 patients treated through TRA. We found that TRA has been used for a wide variety of neurointerventional procedures, including the treatment of aneurysms, arteriovenous malformations, dural arteriovenous fistulas, carotid artery stenosis, intracranial stenosis, MT, and tumor embolization.

In the 1342 cases included in this review there were two (0.15%) major complications and 37 (2.75%) minor complications reported. In 64 cases (4.77%) crossover to TFA was required for completion of the procedure. Seven (0.52%) patients crossed over due to inability to access the radial artery and 57 (4.24%) patients crossed over due to the inability to catheterize the target vessel. Of the 423 aneurysms treated, 20 (4.73%) required crossover to TFA for completion of the procedure and, of the 616 CAS performed through TRA, 35 (5.68%) required crossover to TFA for completion of the procedure.

TRA for carotid artery stenting (CAS)

Recent studies have shown a high procedural success rate for CAS using TRA.31 32 A recent meta-analysis of seven CAS studies performed via TRA showed a pooled procedural successful outcome rate of 90.8% (657/723; 95% CI 86.7% to 94.2%).33 The mean procedural time pooled across five studies33 was 40.5±7.0 min compared with 54±18 min reported in a previous TFA study.34 The procedural success rates were higher for patients with type III or bovine arch morphology. As most neuroendovascular surgeons have experienced, these arch configurations pose particular technical challenges for the procedure using TFA. The technical success rate of TRA CAS is certainly lower than that reported in large TFA studies. A retrospective analysis of a large Japanese registry with 8458 eligible patients revealed a procedural success rate of 99.5%.35 Conversely, Gao et al included only patients with type III arch morphology and showed a 100% success rate in these patients with TRA compared with 90% using TFA.11 These findings suggest that TRA may have anatomical advantages in patients with type III and bovine arch morphology.

All studies included in our review used embolic protection devices for the CAS. Montorsi et al compared the feasibility and safety of using a proximal protection device (Mo.Ma) compared with a distal filter device in CAS.20 Crossover to TFA was required in 1/61 (1.6%) Mo.MA patients compared with 11/153 (7.1%) filter patients mainly due to technical difficulty in engaging the target vessel. They did not report any major vascular complications in the TRA group. Overall, CAS using TRA has comparable results to those done using TFA and can be considered especially in patients with type III or bovine arch morphology.

TRA for aneurysm treatment

In this review there were a total of 423 aneurysms treated. Reporting of rupture status at the time of presentation was done in only 260 cases, of which 95 were ruptured and 165 were unruptured. Chen et al8 reported a series of 49 patients who underwent FD of unruptured intracranial aneurysms. Of the 49 patients, 39 underwent successful FD stent placement through TRA. In the 39 patients undergoing FD placement through TRA, 20 did so with the use of a triaxial system while 9 did so using a biaxial system. Ten patients were converted to TFA after failed attempts using TRA. There were no procedural complications. The reasons for failure included tortuosity of the left ICA or acute angulation of the left ICA origin at the aortic arch in eight patients and severe radial artery spasm resulting in inability to obtain radial access in two patients.

FD may pose unique challenges for TRA, particularly when it is deemed necessary to use a guide catheter larger than 6Fr. Increasing sheath diameters and smaller radial artery diameters (<2.5 mm) are shown to have higher rates of RAO.36 The routine confirmation of radial artery diameter >2.5 mm prior to sheath placement has been advocated by some authors.37 When larger guide catheters are required (eg, 0.88 inch outer diameter), it can be used alone, without placement of a sheath. Peterson et al9 22 have described various combinations of catheters to form triaxial and quadriaxial systems in order to obtain adequate support to perform FD. These results suggest that the desire to use a triaxial system or a large guide catheter (ie, one that is too large for a 6Fr sheath) should not preclude TRA for the treatment of cerebral aneurysms.

TRA for mechanical thrombectomy (MT)

The decreased risk of access site hemorrhagic complications with TRA over TFA may be particularly relevant for MT, as intravenous thrombolysis is often administered concurrently. A recent report by Chen et al found no difference in the single-pass recanalization rate (54.5% vs 55.6%, p=0.949) and the average number of passes (1.9 vs 1.7, p=0.453) in patients undergoing MT via TFA or TRA, respectively.9 Additionally, there were no significant differences in mean access to reperfusion time (61.9 vs 61.1 min, p=0.920), successful revascularization rates (Thrombolysis in Cerebral Infarction score ≥2b 87.9% vs 88.9%, p=1.0), and functional outcomes (modified Rankin Scale score ≤2, 39.4% vs 33.3%, p=0.669) between TFA and TRA cohorts, respectively. TRA may be particularly well suited for stroke patients whose aortic arch anatomy would present a challenge using TFA (eg, type III or bovine aortic arch configurations).

Distal TRA (snuff box approach)

Distal TRA (dTRA) or the snuff box approach is a modification of TRA that has been adopted recently by neurointerventionalists. Cited advantages of dTRA include a reported lower rate of RAO; therefore, it may be especially useful when repeated endovascular procedures are anticipated. Additionally, it permits ergonomic access to the left radial artery—the physician can remain on the right side of the patient with the patient’s left arm resting across their abdomen without uncomfortable supination. The site of the arteriotomy in dTRA is distal to the origin of the superficial palmar arch; this is felt to reduce the risk of ischemic symptoms in the case of arterial occlusion at the access site.38 A recent paper comparing TRA (n=117) with dTRA (n=89) performed for both diagnostic and interventional procedures found no significant differences in access site crossovers or complication rates between the two approaches.25

Procedural failure and crossovers

The overall procedural success rate of TRA was 95.23%; there were 64 (4.77%) patients who crossed over to TFA. Of these, seven (10.93%) patients crossed over due to severe radial artery spasm resulting in the inability to obtain access. Fifty-seven patients (89.06%) crossed over due to the inability to catheterize the target vessel using TRA. However, in only 13 of these cases were the specific challenges discussed: in eight cases aortic arch configuration precluded catheterization and in five cases acute angulation of the ICA origin from the aortic arch was noted.

In a large meta-analysis of 23 randomized trials with 7020 patients comparing TRA versus TFA in patients undergoing coronary angiography or intervention, the crossover rate and procedural failure rate in the TRA group was 5.9% and 4.7%, respectively.1 Compared with cardiac interventions, TRA for neurointerventions has the additional challenge of navigating through tortuous arch into the carotid arteries, which often needs the use of reverse angle catheters and a theoretically higher risk of procedural failures.


Multiple prospective studies have shown that TRA is associated with a significant reduction in access site complications compared with TFA.1 3 5 Asymptomatic RAO is the most common complication reported after TRA. Previous studies in the interventional cardiology literature report rates of asymptomatic RAO between 1% and 10%.5 39 40 Proposed mechanisms for RAO include endothelial injury of the radial artery combined with decreased blood flow after sheath and catheter insertion.41 42 Post-procedural radial artery stenosis, which may further increase the risk of RAO, has been shown to occur within 2 days after TRA in 31% of patients while late development of RAO is reported to occur in up to 28%.43 In this review we found 27 (1.88%) patients who developed RAO. There was only one patient, with a history of Buerger’s disease, who developed severe symptomatic RAO.19 The relatively low rate of symptomatic RAO may, at least in part, be due to the robust collateral supply of the ulnar artery to the forearm and hand.

One of the primary benefits of TRA over TFA is the significant reduction in hemorrhagic access site complications. In a meta-analysis of 76 studies (15 randomized, 61 observational) involving a total of 761, 919 patients comparing TRA with TFA, TRA was associated with a 78% reduction in bleeding and 80% reduction in the need for blood transfusions.44 In our review, hemorrhagic access site complications were found to occur in six patients (0.47%), all of them being minor forearm hematomas and none requiring any transfusions or additional procedures. This demonstrates a significant reduction in hemorrhagic access site complications compared with studies in which TFA was used for neuroendovascular interventions where rates of hemorrhagic complications were reported to be as high as 7.9%.45

Limitations of study

There are several important limitations to the present study. Most importantly, there was significant heterogeneity in reporting primary outcomes (eg, procedural success) and secondary outcomes (eg, complication and crossover rates) among the various studies. The total number of studies included was small (n=21), with wide variation in sample size (n=8–214). Additionally, the results of this review are subject to significant selection and methodology bias, as some studies included only patients undergoing a specific procedure (eg, only CAS or FD). No study included in this review was a randomized controlled study.

Most of the studies included in this review are from institutions with experience in performing TRA for neuroendovascular interventions. Therefore, the results of this review to institutions beginning a transition to TRA from TFA may not capture the learning curve that inevitably occurs when implementing new techniques. Prospective randomized studies with larger sample size are needed objectively to assess the benefits of TRA over the traditional TFA.


In this review we show that TRA has a high rate of procedural success (95.23%) with a low complication rates (2.90%) when used for various neuroendovascular interventional procedures. These results provide some support that TRA may be a viable option beyond just diagnostic cerebral angiography. TRA may actually have advantages for neuroendovascular interventions, as many of these patients require platelet inhibition for concomitant cardiac disease or for their neurointerventional procedure (ie, intracranial stents), are on anticoagulants for coexisting conditions (ie, atrial fibrillation, deep venous thrombosis), or have received intravenous thrombolysis (ie, in the setting of acute ischemic stroke). While TRA is still undergoing growing adoption in the neuroendovascular field, increasing familiarity with the technique, its safety advantages, and the development of TRA-specific neuroendovascular devices are likely to underscore a trend that finds increasing use among neurointerventionalists.


We would like to thank Bichun Ouyang PhD for her help in statistical analysis.


View Abstract


  • Twitter @dr_mchen

  • Contributors All authors have made substantial contributions to the conception or design of the work or the acquisition, analysis or interpretation of data. They were involved in drafting the work or revising it critically for important intellectual content. All authors gave final approval of the version published and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.