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Original research
Endovascular recanalization for non-acute basilar artery occlusions with progressive or recurrent ischemic symptoms: a multicenter clinical experience
  1. Feng Gao1,
  2. Ju Han2,
  3. Xu Guo3,
  4. Xuan Sun1,
  5. Ning Ma1,
  6. Zhongrong Miao1
  1. 1Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  2. 2Department of Interventional Neurology, Shandong Qianfoshan Hospital, Jinan, Shandong, China
  3. 3Department of Interventional Neuroradiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
  1. Correspondence to Dr Feng Gao, Department of Interventional Neuroradiology, Capital Medical University, Beijing, China; gaofengletter{at}sina.com

Abstract

Background There is no consensus on the optimal treatment of non-acute basilar artery occlusion (BAO), and endovascular recanalization still poses a therapeutic challenge for these patients. We report a multicenter clinical experience of endovascular recanalization for symptomatic non-acute BAO and propose an angiographic grouping to determine which patient subgroup most benefits from this treatment.

Methods Forty-two patients with non-acute BAO with progressive or recurrent vertebrobasilar ischemic symptoms who underwent endovascular recanalization were retrospectively analyzed from January 2015 to December 2019. These patients were classified into three subtypes based on their occlusion length and distal collateral reconstruction on angiograms. The rates of technical success, periprocedural complications and outcome, any stroke or death within 1 month, and follow-up data were examined.

Results The success rate of endovascular recanalization was 76.2% (32/42). The rate of periprocedural complications was 14.3% (6/42). In the three subgroups (types I–III) the success rates of endovascular recanalization were reduced (90.0%, 71.4% and 50%, respectively, p=0.023), while the overall rates of periprocedural complications were increased (5.0%, 14.3% and 37.5%, respectively, p=0.034). Type I lesions, with short-segment occlusions and good distal BA collateral reconstruction, showed favorable responses to endovascular recanalization. The median follow-up time was 1 year (IQR 11.0–19.5 months), with any stroke or death during follow-up at a rate of 7.9%.

Conclusion Endovascular recanalization can be safe and feasible for reasonably selected patients with non-acute BAO, especially type I lesions, and offers an alternative choice for those with progressive or recurrent vertebrobasilar ischemic symptoms despite aggressive medical therapy.

  • angioplasty
  • stent
  • stroke
  • technique
  • atherosclerosis

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Footnotes

  • FG and XS contributed equally.

  • Contributors FG: Study concept and design, study conduct, draft paper, critical revision of manuscript. JH: Study conduct, acquisition of data, statistical analysis. XG: Study conduct, acquisition of data, statistical analysis. XS: Study conduct, acquisition of data. NM: Study conduct, acquisition of data. ZM: Study conduct, critical revision of manuscript.

  • Funding This study was funded by National Key R&D Program (2018AAA0102600).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This retrospective study was approved by the Institutional Review Board of Beijing Tiantan hospital (KY-2020-115-01), and the requirement for patient informed consent was waived for review of patient records and images.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request. The datasets generated and/or analyzed during this research are available from the corresponding author upon reasonable request.

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