Background First-pass effect (FPE) defined as a complete or near-complete reperfusion achieved after a single thrombectomy pass is predictive of favorable outcome in acute ischemic stroke (AIS) patients. We aimed to assess whether admission levels of inflammatory markers are associated with FPE.
Methods HIBISCUS-STROKE (CoHort of Patients to Identify Biological and Imaging markerS of CardiovascUlar Outcomes in Stroke) includes AIS patients with large vessel occlusion treated with mechanical thrombectomy following brain MRI. C-reactive protein, interleukin (IL)-6, IL-8, IL-10, monocyte chemoattractant protein-1, soluble tumor necrosis factor receptor I, soluble form suppression of tumorigenicity 2, matrix metalloproteinase-9 (MMP-9), soluble P-selectin, and vascular cellular adhesion molecule-1 were measured in admission sera using an ELISA assay. FPE was defined as a complete or near-complete reperfusion (thrombolysis in cerebral infarction scale (TICI) 2c or 3) after the first pass. A multivariate logistic regression analysis was performed to assess independent factors associated with FPE.
Results A total of 151 patients were included. Among them, 43 (28.5%) patients had FPE. FPE was associated with low admission levels of IL-6, MMP-9, and platelet count, an older age, lack of hypertension, lack of tandem occlusion, a shorter thrombus length, and a reduced procedural time. Following multivariate analysis, a low admission level of IL-6 was associated with FPE (OR 0.66, 95% CI 0.46 to 0.94). Optimal cut-off of IL-6 level for distinguishing FPE from non-FPE was 3.0 pg/mL (sensitivity 92.3%, specificity 42.3%).
Conclusion A lower admission level of IL-6 is associated with FPE.
- inflammatory response
Data availability statement
Data are available upon reasonable request. Further anonymized data can be made available to qualified investigators on request to the corresponding author.
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NN and OFE contributed equally.
Contributors Study design: LM, MO, NN, OFE. Acquisition, analysis, or interpretation of data: all authors. Drafting the manuscript: LM, NN, OFE. Revising the manuscript critically for important intellectual content: TB, AP, CCDS, MB, CA, LD, EO, YB, ND, MO, NM, T-HC. Statistical analysis: LM, CA. Supervision: NN, OFE. Final approval of the version and agreement to be accountable for all aspects of the work: all authors.
Funding This work was supported by the RHU MARVELOUS (ANR-16-RHUS-0009) of Université Claude Bernard Lyon-1 (UCBL), within the program “Investissements d'Avenir” operated by the French National Research Agency (ANR) and the CASDEN prize from CASDEN/Fondation de l’Avenir awarded to Laura Mechtouff.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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