Article Text
Abstract
Background To investigate the prevalence of small ruptured saccular intracranial aneurysms (sIA) in a Chinese cohort and to identify factors associated with rupture status of sIAs.
Methods Consecutive patients with confirmed sIAs by DSA from January 2015 to July 2019 were included. Demographic and aneurysmal features, including maximal diameter, location, irregularity (lobulated or with blebs), and aspect ratio (AR, defined as height divided by neck width) were recorded and analyzed. Mixed effect logistic regression was used in multivariate analysis.
Results We analyzed 1514 sIAs in a Chinese cohort of 1216 patients, including 651 ruptured and 863 unruptured sIAs. Median aneurysm size was 5.7 mm for ruptured aneurysms, with 66.1% <7 mm in maximal diameter, and 40.2% measuring <5 mm. The median PHASES score of ruptured sIAs was 5. In multivariate analysis, male sex, hypertension, locations other than the internal carotid artery, irregularity (lobulated or with blebs), and higher AR were independently associated with rupture status (OR for irregularity, 2.88, 95% CI 2.20 to 3.77, p<0.001; OR for AR, 1.12, 95% CI 1.01 to 1.24, p=0.036). However, maximal diameter was not significantly associated with rupture status (p=0.72).
Conclusions In this cohort, ruptured sIAs were frequently smaller than 7 mm. Shape related features, such as irregularity and higher AR, were associated with the ruptured status of sIAs, irrespective of diameter. PHASES seems to be inadequate in sIA risk stratification. Shape related parameters may be further investigated in prospective studies.
- brain
- aneurysm
- angiography
- subarachnoid
- hemorrhage
Data availability statement
All data relevant to the study are included in the article and the raw data are uploaded as supplementary file. The deidentified participant data that support the findings of this study are available from the first and corresponding authors upon reasonable request.
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Data availability statement
All data relevant to the study are included in the article and the raw data are uploaded as supplementary file. The deidentified participant data that support the findings of this study are available from the first and corresponding authors upon reasonable request.
Footnotes
Twitter @AjayMalhotraRad
Contributors All authors have contributed substantially to the manuscript and approved the submission.
Funding This work was supported by the Scientific Research Fund of Sichuan Provincial People’s Hospital, 2020LY05.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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