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Case series
Preliminary experience with diffuse correlation spectroscopy in acute ischemic stroke neurointerventional procedures
  1. Maxim Mokin1,
  2. Shail Thanki1,
  3. Penaz Parveen Sultana Mohammad2,
  4. Steve Sheehy2,
  5. Kassandra M Jones1,
  6. Ivo Peto1,
  7. Waldo R Guerrero1,
  8. Kunal Vakharia1,
  9. W Scott Burgin3,
  10. Ashwin B Parthasarathy2
  1. 1Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, USA
  2. 2Department of Electrical Engineering, University of South Florida, Tampa, Florida, USA
  3. 3Department of Neurology, University of South Florida College of Medicine, Tampa, Florida, USA
  1. Correspondence to Dr Maxim Mokin, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, USA; mokin{at}


Background Diffuse correlation spectroscopy (DCS) is a non-invasive optical technique that enables continuous blood flow measurements in various organs, including the brain. DCS quantitatively measures blood flow from temporal fluctuations in the intensity of diffusely reflected light caused by the dynamic scattering of light from moving red blood cells within the tissue.

Methods We performed bilateral cerebral blood flow (CBF) measurements using a custom DCS device in patients undergoing neuroendovascular interventions for acute ischemic stroke. Experimental, clinical, and imaging data were collected in a prospective manner.

Results The device was successfully applied in nine subjects. There were no safety concerns or interference with the standard angiography suite or intensive care unit workflow. Six cases were selected for final analysis and interpretation. DCS measurements with photon count rates greater than 30 KHz had sufficient signal-to-noise to resolve blood flow pulsatility. We found an association between angiographic changes in cerebral reperfusion (partial or complete reperfusion established in stroke thrombectomy cases; temporary flow arrest during carotid artery stenting) and those observed intraprocedurally with CBF measurements via DCS. Limitations of the current technology included sensitivity to the interrogated tissue volume under the probe and the effect of local changes in tissue optical properties on the accuracy of CBF estimates.

Conclusion Our initial experience with DCS in neurointerventional procedures showed the feasibility of this non-invasive approach in providing continuous measurement of regional CBF brain tissue properties.

  • Blood Flow
  • Laser
  • Stroke

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  • Contributors MM, WSB, ABP: study concept and design. WRG, MM, IP, ST, KV: data collection. ABP: statistical analysis. MM, ABP: wrote the draft manuscript. All authors: edited the manuscript and approved the final version.

  • Competing interests MM: grant: NIH; consultant: Cerenovus, Medtronic; stock options: Bendit Technologies, Borvo Medical, BrainQ, Endostream, Serenity Medical, Synchron, Sim&Cure, QAS.AI, Quantanosis.AI; Assistant Editor for JNIS. WSB: grant: Athersys, BMS, Florida High Tech Corridor, NIH, Reneuron, VuEssence; consultant: Genentech, VuEssence; stock options: VuEssence; other: PRIME Education. ABP: grant: NIH; stock options: SPKL LLC.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.