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Ischemic stroke
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Intracranial thrombus composition is associated with occlusion location and endovascular treatment outcomes: results from ITACAT multicenter study
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  • Published on: 11 June 2024
    The Importance of Thrombus Composition in Endovascular Treatment Outcomes
    • Mohsen Salimi, MD Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

    Dear Editor,
    I am writing to express my thoughts on the article titled "Intracranial thrombus composition is associated with occlusion location and endovascular treatment outcomes: results from ITACAT multicenter study", recently published in the Journal of NeuroInterventional Surgery (1). This study provides pivotal insights into how thrombus composition affects the efficacy of mechanical thrombectomy (MT) in treating ischemic strokes, highlighting critical aspects that could influence future therapeutic strategies.
    The study's retrospective analysis of 221 patients, examining thrombi retrieved during MT using hematoxylin–eosin staining and CD61 immunostaining, revealed significant associations between thrombus composition and treatment outcomes. The finding that medium distal vessel occlusions (DMVO) had higher platelet proportions than proximal large vessel occlusions (LVO) is particularly noteworthy. Specifically, middle cerebral artery (MCA) M2–M3 segment thrombi had the highest platelet content (PLTPT at 70%), whereas basilar artery thrombi had the lowest (PLTPT at 41%). These differences suggest that occlusion location can be an indicator of thrombus composition, which has crucial implications for tailoring treatment approaches.
    The logistic regression analysis further strengthened the evidence by showing that lower baseline National Institutes of Health Stroke Scale (NIHSS) scores and lower PLTPT were independently associated with s...

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    Conflict of Interest:
    None declared.