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Technical video
Creating elastase aneurysms in rabbits: a video primer
  1. Jonathan Cortese1,2,3,
  2. Esref Alperen Bayraktar1,
  3. Alexander A Oliver1,
  4. Cem Bilgin1,
  5. Yong-Hong Ding1,
  6. Yasuhito Ueki1,
  7. Sarah Lortscher1,
  8. Waleed Brinjikji1,
  9. Ramanathan Kadirvel4,
  10. David F Kallmes1
    1. 1Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
    2. 2NEURI Neurointerventional Radiology, Bicêtre Hospital, Le Kremlin-Bicêtre, France
    3. 3INSERM U1195, Paris-Saclay University, Le Kremlin-Bicêtre, France
    4. 4Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA
    1. Correspondence to Dr Jonathan Cortese, Departement of Radiology, Mayo Clinic, Rochester, Minnesota, USA; cortese.jonathan{at}mayo.edu

    Abstract

    The New Zealand rabbit elastase-induced arterial aneurysm of the right common carotid artery remains a widely used model for assessing the effectiveness and safety of new neuroendovascular devices.1 This model offers a simple and reliable platform for pre-clinical in vivo investigations, crucial for comprehending the biological processes underlying aneurysm healing after endovascular treatment.2 Notably, the induced aneurysm exhibits morphological, hemodynamic, and histological characteristics similar to human intracranial aneurysms. The creation of the aneurysm is performed using open and endovascular techniques. Each step of the procedure requires a meticulous and controlled gesture to ensure reproducibility of the aneurysm and minimize animal misuse. In video 1 we present a step-by-step procedural guide for aneurysm creation and follow-up. We hope this resource will help in promoting this model and provide useful guidance for researchers in the field.

    Video 1 Surgical procedure of creating elastase-induced aneurysms in rabbits.

    • Aneurysm

    https://doi.org/10.1136/jnis-2024-021912

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      Footnotes

      • X @Alex___Oliver, @cembilgincb

      • Contributors JC, EAB, AAO, Y-HD, RK, and DFK contributed to the conception and design of the video. SL, Y-HD, CB, and YU contributed to the acquisition, analysis, or interpretation of data. All authors drafted the work or revised it for significant intellectual content. All authors approved the final version of the manuscript and agree to be accountable for all aspects of the work, including its accuracy and integrity.

      • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

      • Competing interests JC received an educational grant from Balt, Medtronic, Phenox, Microvention, all unrelated to this work. WB received research support from Cerenovus, Sensome and Brainomix and is a stockholder in Piraeus, Serenity, MomEase and Nested Knowledge, all unrelated to this work. RK received research support from Cerenovus, Sensome, Neurogami Medical, Insera Therapeutics, Medtronic, Monarch Biosciences, MiVi, Stryker, Piraeus Medical, Bionaut Labs, NSF and NIH, all unrelated to this work. DFK received research support from Cerenovus, Sensome, Neurogami Medical, Insera Therapeutics, Medtronic, Microvention, Balt, Monarch Biosciences, Brainomix, MiVi, Stryker and NIH; royalties from Medtronic; is on the DSMB of NoNO Inc and Vesalio; and is a stockholder in Nested Knowledge, Superior Medical Experts, Marblehead Medical, and Conway Medical, all unrelated to this work.

      • Provenance and peer review Not commissioned; externally peer reviewed.