I read with interest the paper by Pierot et al [1]. They conducted a prospective study to examine factors of delayed thromboembolic events in 335 patients after coiling of unruptured intracranial aneurysms. The number of delayed TEEs was 8. The adjusted odds ratios (95% confidence intervals) of autosomal dominant polycystic kidney disease and post-procedure aneurysm remnant at procedure completion for delayed TEEs were 27.3 (3.9 to 190.2) and 9.9 (1.0 to 51.3), respectively. They understand the lack of statistical power in the multivariate analysis and did not intend to examine the causal association. I present a comment regarding the number of events in logistic regression analysis.
The limitation in the total number of events for logistic regression analysis was simulated to improve statistical power [2]. In addition, Peduzzi et al. evaluated the effect of the number of events per variable (EPV) on the outcome in logistic regression analysis [3], concluding that the number of EPV less than 10 has some problems for the prediction of dependent variable. There is an opinion that EPV value less than 10 is also acceptable to evaluate the association by logistic regression analysis [4]. Pierot et al. observed 8 events, which was not appropriate for multivariate analysis even for examining the association instead of prediction in a prospective study. I think that wide ranges of 95% confidence intervals may reflect unstable estimates in a logistic regr...
I read with interest the paper by Pierot et al [1]. They conducted a prospective study to examine factors of delayed thromboembolic events in 335 patients after coiling of unruptured intracranial aneurysms. The number of delayed TEEs was 8. The adjusted odds ratios (95% confidence intervals) of autosomal dominant polycystic kidney disease and post-procedure aneurysm remnant at procedure completion for delayed TEEs were 27.3 (3.9 to 190.2) and 9.9 (1.0 to 51.3), respectively. They understand the lack of statistical power in the multivariate analysis and did not intend to examine the causal association. I present a comment regarding the number of events in logistic regression analysis.
The limitation in the total number of events for logistic regression analysis was simulated to improve statistical power [2]. In addition, Peduzzi et al. evaluated the effect of the number of events per variable (EPV) on the outcome in logistic regression analysis [3], concluding that the number of EPV less than 10 has some problems for the prediction of dependent variable. There is an opinion that EPV value less than 10 is also acceptable to evaluate the association by logistic regression analysis [4]. Pierot et al. observed 8 events, which was not appropriate for multivariate analysis even for examining the association instead of prediction in a prospective study. I think that wide ranges of 95% confidence intervals may reflect unstable estimates in a logistic regression analysis.
Their study is important for clarifying risk factors of delayed thromboembolic events even though the prevalence of adverse effect is low. I recommend that EPV should be kept higher by making larger sample sizes for keeping stable risk estimation.
REFERENCES
[1] Pierot L, Barbe C, Herbreteau D, et al. Delayed thromboembolic events after coiling of unruptured intracranial aneurysms in a prospective cohort of 335 patients. J Neurointerv Surg 2021;13(6):534-540.
[2] Novikov I, Fund N, Freedman LS. A modified approach to estimating sample size for simple logistic regression with one continuous covariate. Stat Med 2010;29(1):97-107.
[3] Peduzzi P, Concato J, Kemper E, et al. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996;49(12):1373-1379.
[4] Vittinghoff E, McCulloch CE. Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 2007;165(6):710-718.
We have read with great interest the article entitled “Efficacy and mid-term outcome of middle meningeal artery embolization with or without burr hole evacuation for chronic subdural hematoma compared with burr hole evacuation alone” by Onyinzo, C., et al, published in Journal of NeuroInterventional Surgery (2021).
The article has compared the Surgical and Endovascular management of (CSDH) in the elderly population who are at high risk to developing (CSDH) due to their co-morbidities and the use of anti-thrombotic agents.
It is noted that the anti-thrombotic agents were stopped to both management arms. Upfront Middle meningeal artery embolization without stopping the anti-thrombotics, might be a strategy to mitigate the risk of cardio-embolic events.
In regards to the evaluation of the patients outcome, clinical parameters did not include motor assessment, which is a significant factor to favor a rapid surgical evacuation in these delicate patients.
As to the radiological follow up, cured (CSDH) were defined in the article with a thickness less than 10 mm. This is debatable as there are a lot of variations exists for this population in regards to brain volume and brain elasticity.
Finally, we would like to point out the timing of the follow up was not defines for all patients. This need to be harmonized better to a well-defined follow up timeline. Joyce, MD, et al,2 a suggested a time frame of 6 weeks after the treatment...
We have read with great interest the article entitled “Efficacy and mid-term outcome of middle meningeal artery embolization with or without burr hole evacuation for chronic subdural hematoma compared with burr hole evacuation alone” by Onyinzo, C., et al, published in Journal of NeuroInterventional Surgery (2021).
The article has compared the Surgical and Endovascular management of (CSDH) in the elderly population who are at high risk to developing (CSDH) due to their co-morbidities and the use of anti-thrombotic agents.
It is noted that the anti-thrombotic agents were stopped to both management arms. Upfront Middle meningeal artery embolization without stopping the anti-thrombotics, might be a strategy to mitigate the risk of cardio-embolic events.
In regards to the evaluation of the patients outcome, clinical parameters did not include motor assessment, which is a significant factor to favor a rapid surgical evacuation in these delicate patients.
As to the radiological follow up, cured (CSDH) were defined in the article with a thickness less than 10 mm. This is debatable as there are a lot of variations exists for this population in regards to brain volume and brain elasticity.
Finally, we would like to point out the timing of the follow up was not defines for all patients. This need to be harmonized better to a well-defined follow up timeline. Joyce, MD, et al,2 a suggested a time frame of 6 weeks after the treatment and then at 90 days
We believe these points will bridge the findings of the authors to the real-world practice, by accounting for more clinical and radiological parameters to consolidate recommendations of practice.
References
Catapano, J. S., Nguyen, C., Wakim, A., Albuquerque, F., & Ducruet, A. (2020). Joshua S. Catapano. Frontiers in Neurology , 11. https://doi.org/10.3389/fneur.2020.557233
Joyce, E., Bounajem, M. T., Scoville, J., Thomas, A. J., Ogilvy, C. S., Riina, H. A., Tanweer, O., Levy, E. I., Spiotta, A. M., Gross, B. A., Jankowitz, B. T., Cawley, C. M., Khalessi, A. A., Pandey, A. S., Ringer, A. J., Hanel, R., Ortiz, R. A., Langer, D., Levitt, M. R., … Grandhi, R. (2020). Middle meningeal artery embolization treatment of nonacute subdural hematomas in the elderly: a multiinstitutional experience of 151 cases. Neurosurgical Focus, 49(4). https://doi.org/10.3171/2020.7.focus20518
Jumah, F., Osama, M., Islim, A. I., Jumah, A., Patra, D. P., Kosty, J., Narayan, V., Nanda, A., Gupta, G., & Dossani, R. H. (2020). Efficacy and safety of middle meningeal artery embolization in the management of refractory or chronic subdural hematomas: a systematic review and meta-analysis. Acta Neurochirurgica, 162(3), 499–507. https://doi.org/10.1007/s00701-019-04161-3
Srivatsan, A., Mohanty, A., Nascimento, F. A., Hafeez, M. U., Srinivasan, V. M., Thomas, A., Chen, S. R., Johnson, J. N., & Kan, P. (2019). Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: Meta-Analysis and Systematic Review. World Neurosurgery, 122, 613–619. https://doi.org/10.1016/j.wneu.2018.11.167
We read with great interest the recent paper by Vargas, et al. describing a novel beveled tip aspiration catheter with improved recanalization and patient outcome compared to conventional non-beveled tip catheters in a single-center retrospective study.[1] We want to express our sincere congratulations to the authors on this finding but also want to respectively present our disagreement on the mechanisms explaining the improved performance of the beveled tip catheter as compared to standard catheters.
The authors conclude that a primary reason for higher rate of complete clot ingestion for the beveled tip catheter relates to the area of the catheter tip. It is widely accepted that ingestion force predicts recanalization efficacy, and this force is proportional to tip area (A) and pressure drop (P). The authors note that the beveled tip leads to an ovalized tip area with a total tip area that is approximately 15% larger than a catheter with an equivalent inner diameter but standard non-beveled tip. They then propose that this 15% increase in tip area leads to a corresponding increase of ingestion force, using the standard F=A*P equation. However, this proposition is flawed. While it is true the total force is larger for the beveled tip catheter than a standard catheter, this total force includes two separate force components that are orthogonal to each other, including the ingestion force component (along the catheter’s length) that corks or ingests the clot and...
We read with great interest the recent paper by Vargas, et al. describing a novel beveled tip aspiration catheter with improved recanalization and patient outcome compared to conventional non-beveled tip catheters in a single-center retrospective study.[1] We want to express our sincere congratulations to the authors on this finding but also want to respectively present our disagreement on the mechanisms explaining the improved performance of the beveled tip catheter as compared to standard catheters.
The authors conclude that a primary reason for higher rate of complete clot ingestion for the beveled tip catheter relates to the area of the catheter tip. It is widely accepted that ingestion force predicts recanalization efficacy, and this force is proportional to tip area (A) and pressure drop (P). The authors note that the beveled tip leads to an ovalized tip area with a total tip area that is approximately 15% larger than a catheter with an equivalent inner diameter but standard non-beveled tip. They then propose that this 15% increase in tip area leads to a corresponding increase of ingestion force, using the standard F=A*P equation. However, this proposition is flawed. While it is true the total force is larger for the beveled tip catheter than a standard catheter, this total force includes two separate force components that are orthogonal to each other, including the ingestion force component (along the catheter’s length) that corks or ingests the clot and a perpendicular force directed against the catheter wall, which does not affect ingestion. In fact, the ingestion force is exactly the same between the beveled catheter and standard tip catheters, and is calculated as A*P, where A is simply the area of the ID of the catheter, as with standard catheters.
We think several other possible mechanisms underlie the improved recanalization outcome with the beveled tip catheter as compared to standard catheters. First, as the authors addressed in the discussion, the beveled tip enables better alignment of the catheter’s main axis and the ingestion force to the clot’s main axis , which allows a larger force transmitted to the clot than those with standard catheters.[2] Second, the bevel could partially separate the clot from the vessel wall, reducing the friction and enabling easier clot ingestion. Third, in the cases of the beveled tip advanced to be flush with the clot face, the space between the bevel tip and the bevel base can enable non-contact aspiration,[3] where the clot ingestion is enhanced by the retrograde aspiration blood flow. In comparison, for contact aspiration with standard catheters, the clot blocks the entire catheter tip and no retrograde flow will be created to facilitate clot ingestion.
Overall, the clinical results are very encouraging, and we hope our comments can benefit our community to achieve a more comprehensive understanding of the action mechanism of the beveled tip catheter in our community. Additional mechanistic study is warranted.
References
1. Vargas J, Blalock J, Venkatraman A, et al. Efficacy of beveled tip aspiration catheter in mechanical thrombectomy for acute ischemic stroke. J Neurointerv Surg. Published online 2020:1-5.
2. Bernava G, Rosi A, Boto J, et al. Direct thromboaspiration efficacy for mechanical thrombectomy is related to the angle of interaction between the aspiration catheter and the clot. J Neurointerv Surg. 2020;12(4):396-400.
3. Haussen DC, Bouslama M, Grossberg JA, Nogueira RG. Remote aspiration thrombectomy in large vessel acute ischemic stroke. J Neurointerv Surg. 2017;9(3):250-252.
We congratulate Drs. Srivatsan and colleagues on their paper examining the effects of endovascular coiling of unruptured intracranial aneurysms (UIAs) on cognition using the Montreal Cognitive Assessment (MoCA).1 In particular, we appreciate the efforts made to sample the patients at multiple time points including pre-intervention and at 1-month and 6-months post-intervention. The study found that coiling did not diminish neurocognitive function per the MoCA, with there also being no correlation between follow-up MoCA scores and imaging findings, the overall results being comparable to the authors’ previous paper on MoCA scores following flow diversion for UIAs.2 Intriguingly, the MoCA scores at baseline were on average below the typical cut-off of 26 points, especially given the relatively young population (mean age 55.5 years).
However, as acknowledged by the authors, the ability of the study to discern post-coiling imaging changes was limited by both the small subset of the population that received follow-up imaging (17 of 33 patients, 51.5%) and the smaller subset that underwent MRI (9 patients, 27.3%).1 Diffusion-weighted imaging (DWI) sequences of MRI are most sensitive to identifying post-procedural ischemic injury following neuro-interventional procedures like coiling.3 DWI lesions occur quite frequently; for example, in the ENACT trial (Evaluating Neuroprotection in Aneurysm Coiling Therapy), 68% of patients had new lesions post-procedure, with an average o...
We congratulate Drs. Srivatsan and colleagues on their paper examining the effects of endovascular coiling of unruptured intracranial aneurysms (UIAs) on cognition using the Montreal Cognitive Assessment (MoCA).1 In particular, we appreciate the efforts made to sample the patients at multiple time points including pre-intervention and at 1-month and 6-months post-intervention. The study found that coiling did not diminish neurocognitive function per the MoCA, with there also being no correlation between follow-up MoCA scores and imaging findings, the overall results being comparable to the authors’ previous paper on MoCA scores following flow diversion for UIAs.2 Intriguingly, the MoCA scores at baseline were on average below the typical cut-off of 26 points, especially given the relatively young population (mean age 55.5 years).
However, as acknowledged by the authors, the ability of the study to discern post-coiling imaging changes was limited by both the small subset of the population that received follow-up imaging (17 of 33 patients, 51.5%) and the smaller subset that underwent MRI (9 patients, 27.3%).1 Diffusion-weighted imaging (DWI) sequences of MRI are most sensitive to identifying post-procedural ischemic injury following neuro-interventional procedures like coiling.3 DWI lesions occur quite frequently; for example, in the ENACT trial (Evaluating Neuroprotection in Aneurysm Coiling Therapy), 68% of patients had new lesions post-procedure, with an average of 4.3 new lesions in the NA-1 arm and 6.7 lesions in the placebo arm when considering just the 147 patients with UIAs.4 Future studies will need to examine the relationship between the burden of such DWI lesions and post-procedural cognitive outcomes in further detail.
Furthermore, although the MoCA is a useful global assessment of cognitive impairment, we suspect that it may have more limited sensitivity in identifying mild post-procedural cognitive changes. As the studies by Drs. Strivatsan and colleagues with post-coiling and post-flow-diversion outcomes have shown, any potential changes are likely to be subtle. As we seek to uncover the phenotype of potential cognitive deficits after endovascular procedures for UIAs, we may seek guidance from the existing literature on vascular cognitive impairment (VCI), which is known to have a preponderance of executive dysfunction, including slowed information processing, impaired set-/task-shifting, and deficits in working memory.5 6 To help assess such domains with greater granularity, the National Institute of Neurological Disorders and Stroke (NINDS) and the Canadian Stroke Network (CSN) have proposed cognitive testing protocols as part of the NINDS-CSN VCI Harmonization Standards.7 Of the 5-minute, 30-minute, and 60-minute protocols proposed, the 30-minute test protocol (applied in the ENACT trial)4 appears to offer a helpful balance of length and granularity, with specific measures of the aforementioned domains like the Controlled Oral Word Association Test (COWAT – phonemic fluency), semantic fluency, Digit Symbol-Coding, the Hopkins Verbal Learning Test (HVLT), the Trail Making Test, as well as brief assessments of neuropsychiatric symptoms through the Center for Epidemiologic Studies – Depression (CES-D) scale and the Neuropsychiatric Inventory, Questionnaire Version (NPI-Q).7 Future studies of post-procedural cognitive changes should seek to incorporate some or all of these additional tests into their follow-up testing protocols.
References
1. Srivatsan A, Mohanty A, Saleem Y, et al. Cognitive outcomes after unruptured intracranial aneurysm treatment with endovascular coiling. J Neurointerv Surg 2020 doi: 10.1136/neurintsurg-2020-016362 [published Online First: 2020/07/24]
2. Wagner K, Srivatsan A, Mohanty A, et al. Cognitive outcomes after unruptured intracranial aneurysm treatment with flow diversion. J Neurosurg 2019:1-6. doi: 10.3171/2019.9.JNS191910 [published Online First: 2019/11/30]
3. Iosif C, Camilleri Y, Saleme S, et al. Diffusion-weighted imaging-detected ischemic lesions associated with flow-diverting stents in intracranial aneurysms: safety, potential mechanisms, clinical outcome, and concerns. J Neurosurg 2015;122(3):627-36. doi: 10.3171/2014.10.JNS132566 [published Online First: 2015/01/07]
4. Hill MD, Martin RH, Mikulis D, et al. Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol 2012;11(11):942-50. doi: 10.1016/S1474-4422(12)70225-9
5. Garrett KD, Browndyke JN, Whelihan W, et al. The neuropsychological profile of vascular cognitive impairment--no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia. Arch Clin Neuropsychol 2004;19(6):745-57. doi: 10.1016/j.acn.2003.09.008 [published Online First: 2004/08/04]
6. Nyenhuis DL, Gorelick PB, Geenen EJ, et al. The pattern of neuropsychological deficits in Vascular Cognitive Impairment-No Dementia (Vascular CIND). Clin Neuropsychol 2004;18(1):41-9. doi: 10.1080/13854040490507145 [published Online First: 2004/12/15]
7. Hachinski V, Iadecola C, Petersen RC, et al. National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 2006;37(9):2220-41. doi: 10.1161/01.STR.0000237236.88823.47
After reading the interesting article by Jeon et al, indeed, the first series of cases of revascularization in cerebral infarction, it is important to point out several aspects related to the cancer patient. Cancer is a heterogeneous group of diseases with some points in common related to cellular behavior in the face of cell division controls and their local and systemic effects. Its incidence and prevalence are increasing, and the borders of treatment are changing, as is the disease itself. Patients with active cancer, therefore, should be approached in a multidisciplinary strategy, for the management of their oncological pathology or associated patient comorbidities. Stroke does not escape this strategy, because it does not have the same clinical impact to treat a patient with an oncological disease in early staging compared to one in advanced staging or in disease progression in palliative care and short calculated survival. It is not possible to establish a general rule of treatment in stroke with active cancer for these reasons, and a careful analysis of which primary tumors, their staging or clinical evolution of response to treatment, are necessary to clarify the clinical picture of stroke treatment in the oncological disease context.
Kaminsky et al1 present an interesting study regarding the logistics of patients eligible for endovascular stroke therapy (EVT). They conclude that whether patients with large vessel occlusion (LVO) are first admitted to a hospital with or without this treatment does not affect patient outcome.
However, there are some difficulties interpreting the main statistical multivariate analyses. Firstly, although there is a clear presentation of how the main multivariate logistic regression analysis is performed, the covariates included in the model are not presented, and the model is not shown in any table. Secondly, the authors have included variables solely based on the strength of their association with the outcome, and not based on the potential of the variable to confound the relationship between the variable of interest (which center the patient is admitted to first), and the outcome. In this setting, it is our opinion that selecting covariates based on an etiological model, that focuses on the variable of interest, and includes covariates based on the potential for confounding, would be the best strategy.2 We disagree with the authors` choice of a prognostic model.
We urge the authors to provide a table showing the main analysis, or even repeat the main analysis using an etiological approach to model building and variable selection.
Despite these shortcomings, we commend the authors for undertaking such a relevant clinical study, and we...
Kaminsky et al1 present an interesting study regarding the logistics of patients eligible for endovascular stroke therapy (EVT). They conclude that whether patients with large vessel occlusion (LVO) are first admitted to a hospital with or without this treatment does not affect patient outcome.
However, there are some difficulties interpreting the main statistical multivariate analyses. Firstly, although there is a clear presentation of how the main multivariate logistic regression analysis is performed, the covariates included in the model are not presented, and the model is not shown in any table. Secondly, the authors have included variables solely based on the strength of their association with the outcome, and not based on the potential of the variable to confound the relationship between the variable of interest (which center the patient is admitted to first), and the outcome. In this setting, it is our opinion that selecting covariates based on an etiological model, that focuses on the variable of interest, and includes covariates based on the potential for confounding, would be the best strategy.2 We disagree with the authors` choice of a prognostic model.
We urge the authors to provide a table showing the main analysis, or even repeat the main analysis using an etiological approach to model building and variable selection.
Despite these shortcomings, we commend the authors for undertaking such a relevant clinical study, and we agree on the need for randomized trials in this field.
1. Kaminsky AL, Mione G, Omorou Y, et al. Outcome of patients with large vessel occlusion stroke after first admission in telestroke spoke versus comprehensive stroke center. J Neurointerv Surg 2019 doi: 10.1136/neurintsurg-2019-015342
2. Tripepi G, Jager KJ, Dekker FW, et al. Testing for causality and prognosis: etiological and prognostic models. Kidney International 2008;74(12):1512-15. doi: https://doi.org/10.1038/ki.2008.416
We read with great joy the recent article by Kuhn et al entitled, “ Distal radial access in the anatomical snuffbox for neurointerventions: a feasibility, safety, and proof-of-concept study.” The authors should be congratulated on their work, as well as the use and maturation of the distal radial technique from diagnostic to interventional procedures. The authors detail their use of the Prelude sheaths which we agree are excellent low profile large lumen sheaths for radial access. We typically utilize the Glide Slender sheaths (Terumo) but both are excellent options. We also agree that the distal radial approach can be used for numerous interventions with access sizes from 4 to 6F, including 6F sheathless long 088 guides. Our choice for distal radial sheathless long 088 guides is Infinity LS (Stryker), and for 071 guides the Benchmark (penumbra) via a 6F sheath.
The authors noted their series was the first series to cover numerous neurointerventions with distal transradial access, however we would like to respectfully point out that we published on this topic in January of 2019 (accepted in March of 2019). Our paper by Rajah et al entitled, “ Snuff box radial access: A technical note on distal radial access for neuroendovascular procedures” can be found in Brain Circulation at the following citation available in PUBMED.
Rajah G, Garling RJ, Hudson M, Luqman A. Snuff box radial access: A technical note on distal radial access for neuroe...
We read with great joy the recent article by Kuhn et al entitled, “ Distal radial access in the anatomical snuffbox for neurointerventions: a feasibility, safety, and proof-of-concept study.” The authors should be congratulated on their work, as well as the use and maturation of the distal radial technique from diagnostic to interventional procedures. The authors detail their use of the Prelude sheaths which we agree are excellent low profile large lumen sheaths for radial access. We typically utilize the Glide Slender sheaths (Terumo) but both are excellent options. We also agree that the distal radial approach can be used for numerous interventions with access sizes from 4 to 6F, including 6F sheathless long 088 guides. Our choice for distal radial sheathless long 088 guides is Infinity LS (Stryker), and for 071 guides the Benchmark (penumbra) via a 6F sheath.
The authors noted their series was the first series to cover numerous neurointerventions with distal transradial access, however we would like to respectfully point out that we published on this topic in January of 2019 (accepted in March of 2019). Our paper by Rajah et al entitled, “ Snuff box radial access: A technical note on distal radial access for neuroendovascular procedures” can be found in Brain Circulation at the following citation available in PUBMED.
Rajah G, Garling RJ, Hudson M, Luqman A. Snuff box radial access: A technical note on distal radial access for neuroendovascular procedures. Brain circulation. 2019 Jan;5(1):36.
Our paper details our technique, the pros of anatomic orientation of the hand for both the patient and surgeon, as well as the theoretical safety of the distal radial approach with regards to ischemia. We detail how our access is performed with ultrasound, and depict 4 illustrative case examples with imaging including aneurysm stent coiling, head and neck embolization, posterior fossa parent vessel sacrifice, and carotid stenting via a sheathless approach. We had switched over our entire practice for surgeon (AL) to distal radial access in November of 2018. Since that time all diagnostic angiograms and most interventions were performed via distal radial access including ischemic strokes. We have a distal radial manuscript currently accepted to Brain Circulation detailing our use of a Balloon guide catheter for ischemic stroke, which we admit still has its limitations with the available current guides due to outside diameter (OD) and stiffness. However with newest Balloon guides recently approved by the FDA, such as those made by Q’Apel, Medical boasting an 087 ID with a flexible design may provide for sheathless radial use. A 7F 072 balloon guide is also advertised by the Q’Apel. Kuhn et al explains distal radial access can provide enough support for flow divertor deployment intracranially, we echo this finding, as we have also treated aneurysms and carotid cavernous fistulas via a distal radial approach with flow divertors in tandem or stacked fashion.
We again applaud the authors on their work, and are excited to see the field moving toward more distal radial access during the current radial revolution in the neuro endovascular world. We agree with the authors this technique is a safe and effective way to perform a variety of endovascular procedures and should be in every surgeons armamentarium.
Haussen et al described a technique of blind exchange with mini-pinning technique (BEMP) for distal occlusion thrombectomy. The authors are to be commended for a well-written article show-casing an important technique for reperfusing distal occlusions in eloquent territories. We recently used a variation of this technique for mechanical thrombectomy in a large proximal vessel occlusion to great effect.
A 64-year-old man with atrial fibrillation presented to our institution with a right ICA terminus occlusion and NIHSS 17. Mechnical thrombectomy with a Solitaire retriever and 6F aspiration catheter (Solumbra technique) was attempted, but could not be performed due to marked tortuosity of the aortic arch and right cervical ICA, which prevented the aspiration catheter from reaching the clot. Two passes were attempted with the stentriever alone, without success (TICI 0). Therefore, a Trevo stentriever was advanced through the right ICA occlusion via a Markman microcatheter, the microcatheter was removed, and a 3MAX aspiration catheter was advanced over the retriever delivery wire. The stent was left in place for 5 minutes, and the thrombus was retrieved under continuous aspiration after partial ingestion/corking of the thrombus into the 3MAX aspiration catheter (BEMP). This was performed for a total of 2 passes, at the end of which there was complete revascularization of the right MCA territory (TICI 3).
The BEMP technique described by Haussen et al is an import...
Haussen et al described a technique of blind exchange with mini-pinning technique (BEMP) for distal occlusion thrombectomy. The authors are to be commended for a well-written article show-casing an important technique for reperfusing distal occlusions in eloquent territories. We recently used a variation of this technique for mechanical thrombectomy in a large proximal vessel occlusion to great effect.
A 64-year-old man with atrial fibrillation presented to our institution with a right ICA terminus occlusion and NIHSS 17. Mechnical thrombectomy with a Solitaire retriever and 6F aspiration catheter (Solumbra technique) was attempted, but could not be performed due to marked tortuosity of the aortic arch and right cervical ICA, which prevented the aspiration catheter from reaching the clot. Two passes were attempted with the stentriever alone, without success (TICI 0). Therefore, a Trevo stentriever was advanced through the right ICA occlusion via a Markman microcatheter, the microcatheter was removed, and a 3MAX aspiration catheter was advanced over the retriever delivery wire. The stent was left in place for 5 minutes, and the thrombus was retrieved under continuous aspiration after partial ingestion/corking of the thrombus into the 3MAX aspiration catheter (BEMP). This was performed for a total of 2 passes, at the end of which there was complete revascularization of the right MCA territory (TICI 3).
The BEMP technique described by Haussen et al is an important one to keep in mind for any neurovascular center with a busy stroke practice. In addition to distal occlusions, it can also be used as a salvage technique for large proximal occlusions that would be otherwise inaccessible to large bore aspiration catheters.
We thank the respondents for providing their case experience and allowing further discussion of this important topic. We would first like to draw attention to specific points in the described case, before discussing some of the more general issues raised.
The respondents report one of many scenarios in which it may be undesirable to use dual antiplatelet therapy in the elective treatment of intracranial aneurysms with flow diverters. In this case, a 47-year-old woman with an 11 mm left ophthalmic aneurysm harbours a significant aspirin allergy. A single Pipeline Shield device under cover of ticagrelor was used to treat the aneurysm. The patient was well at discharge on postoperative day three but then developed symptomatic stent thrombosis on day 6. We draw attention to three points:
1) The respondents state that the stent achieved “perfect wall apposition improved with intra-stent balloon angioplasty.” Setting aside the impossibility of improving “perfect wall apposition” with angioplasty, this does allude to the increasingly understood importance of flow diverter wall apposition. [1] However, digital subtraction angiography assess stent apposition poorly. [1] The use of angioplasty suggests that there may have been some initial concern. Moreover, angioplasty itself may contribute to thrombosis if it promotes activation of the extrinsic clotting pathway by disrupting the endothelial layer. The phosphocholine “Shield” layer reduces thrombosis and platelet...
We thank the respondents for providing their case experience and allowing further discussion of this important topic. We would first like to draw attention to specific points in the described case, before discussing some of the more general issues raised.
The respondents report one of many scenarios in which it may be undesirable to use dual antiplatelet therapy in the elective treatment of intracranial aneurysms with flow diverters. In this case, a 47-year-old woman with an 11 mm left ophthalmic aneurysm harbours a significant aspirin allergy. A single Pipeline Shield device under cover of ticagrelor was used to treat the aneurysm. The patient was well at discharge on postoperative day three but then developed symptomatic stent thrombosis on day 6. We draw attention to three points:
1) The respondents state that the stent achieved “perfect wall apposition improved with intra-stent balloon angioplasty.” Setting aside the impossibility of improving “perfect wall apposition” with angioplasty, this does allude to the increasingly understood importance of flow diverter wall apposition. [1] However, digital subtraction angiography assess stent apposition poorly. [1] The use of angioplasty suggests that there may have been some initial concern. Moreover, angioplasty itself may contribute to thrombosis if it promotes activation of the extrinsic clotting pathway by disrupting the endothelial layer. The phosphocholine “Shield” layer reduces thrombosis and platelet aggregation via retarding activation of clotting factor XII at the stent surface(intrinsic pathway). It will exert no effect on the extrinsic pathway should it be activated.
2) The respondents do not mention if platelet response to ticagrelor was tested. This is not a criticism, as it is common to use new generation P2Y12 antagonists without testing their efficacy. However, it is also essential to understand ticagrelor resistance is reported in up to 3% of the population. [2] More recently we have experienced stent occlusions using the aspirin only technique in patients who were subsequently found to be aspirin non-responders. Given the loss of redundancy inherent in a single antiplatelet therapy (SAPT) technique, anti-platelet response testing should be reconsidered.
3) The timing of the symptomatic stent occlusion is noteworthy as it occurred three days post-discharge from hospital. This is somewhat unusual, as typically SAPT stent occlusions occur more acutely. Ticagerol’s shorter half-life means its effect will be subtherapeutic if discontinued for three days. Therefore, given the suspicious timing of the patient's stent occlusion, issues with patient compliance should be considered.
The use of the Pipeline Shield with aspirin only is a technique reserved for extreme circumstances. In aneurysmal SAH patients who cannot be treated successfully without the use of a stent and in whom antiplatelet therapy is undesirable or contraindicated, this technique may be appropriate. This has been stated in the original manuscript and is apparent in the description of the aneurysms treated. Our study reported an asymptomatic thromboembolic complication rate of 14.3% and a symptomatic rate of 7.1%. [3] Given the complex and extremely challenging nature of these cases, a symptomatic thromboembolic complication rate of 7.1% may be acceptable. The respondents point out that the combined rate is 21.4%. Any complications are too many, however, bear in mind that the thromboembolic complication rate in CLARITY was 12.5%. [4] Given the latter patient population underwent routine aneurysm coiling and the former represents patients without conventional treatment options this difference seems acceptable. Moreover, the symptomatic thromboembolic complication rate in the SAPT study is not very different from that reported in either ASPIRe or IntrePED. [5,6]
We believe that the addition of the phosphocholine "Shield" surface modification may allow greater flexibility in the use of antiplatelet therapy. It is increasingly clear that antiplatelet therapy is central to complications with flow diverting stents. Recent meta-analysis demonstrates that a hypo-response to DAPT increases the risk of thromboembolic complications and that a hyper-response increases the risk of haemorrhagic complications. [7] In the setting of acute aneurysm rupture, antiplatelet therapy is even more critical. The use of DAPT in such patients has been shown to increase the risks of haemorrhagic complications dramatically. [8] Therefore, any technology that may reduce our reliance on antiplatelet therapy should be fully explored.
The use of SAPT in complex ruptured aneurysms has nuanced advantages that may not be apparent to all readers. Many operators choose to delay treatment of ruptured aneurysms requiring a flow diverter to avoid dual antiplatelet therapy (DAPT) acutely. The mean time from subarachnoid haemorrhage (SAH) to aneurysm treatment in our study was one day. In comparison to 7 days in the meta-analysis reported by Cagnazzo et al. [9] This is particularly important to bear in mind when comparing retrospective studies as patients who re-ruptured before treatment will be excluded from analysis, however, undoubtedly represent treatment failure. This point is highlighted in a recent report by ten Brick and colleagues. [10] In this study, 44 patients with aneurysmal subarachnoid haemorrhage were treated with flow diverting stents on DAPT in five European centres. A range of flow diverters were used. However, none had the "Shield" surface modification. Aneurysm and patients characteristics were similar to the SAPT series we reported. Aneurysms were treated acutely (mean of three days post-SAH), although not as early as in the SAPT study. [3] Procedure-related complications occurred in 44%. Permanent neurological deficit due to procedure-related complications occurred in 27%. Perhaps of most interest to this discussion, post-procedure intracranial bleeding occurred in 22.7% including five aneurysm re-bleeds, two intraparenchymal haemorrhages not related to ventriculostomy, two ventricular shunt-related haemorrhages and one extra-axial haemorrhage. With extracranial haemorrhagic complications reported in another 9.1%. [10] In the SAPT series, two aneurysm re-bleeds occurred with one patient making a full recovery. The other patient, who was already a poor WFNS grade SAH never regained consciousness from the initial ictus. Both patients were being treated with postoperative heparin infusion at the time of aneurysm re-rupture, a practice which was subsequently abandoned as described in the original manuscript. In spite of similar patient and aneurysm characteristics, the DAPT case series reported good clinical outcomes in 45.5% compared to 64.3% in the SAPT series. Procedure-related mortality occurred in 11.4% and 7.1% of the DAPT and SAPT series, respectively.
Finally, it is essential to clarify the use of the term single antiplatelet therapy (SAPT). We are forced to take considerable responsibility for any misuse of this term. One should not consider the use of only one agent as the goal of this work. Instead, the goal is to offer patients with complex ruptured aneurysms, treatment using flow diverting (or other) stents with as little suppression of platelet function as is possible to avoid thromboembolic complications. The term "single antiplatelet therapy" has begun to appear in the literature, regarding the use of agents such as ticagrelor and prasugrel. Such terminology is literally correct; however, it misses the real goal of this work. As compared to P2Y12 antagonists, aspirin has a much less pronounced effect on platelet function and naturally, less haemorrhagic complication risk. [11] In most patients, agents such as ticagrelor and prasugrel likely suppress platelet function to such a degree that they make the addition of aspirin mostly redundant. [12,13]
We agree that further investigation of this technique is required, as stated in the original article. However, we think a randomised control trial would be inappropriate at this stage. It is somewhat facile to call for a randomised control trial to solve all medical dilemmas. It is safe to say that no treatment option is established for patients harbouring such complex ruptured aneurysms and therefore deciding on a control group would be somewhat arbitrary.
Furthermore, it is likely to be challenging to detect a significant difference in clinical outcomes given the uncertain prognosis of such patients independent of how their aneurysms are secured. Therefore, the number of patients that would need to be randomised likely exceeds 1000. We have elected to take a different approach and will study the Pipeline Shield SAPT technique in a multicentre, single-arm, prospective study. We hope that the first patients will be enrolled before this letter is published. The study will begin in Australia; however, it is planned to expand to other countries, and we encourage experienced and skilled centres such as yours to be a part of this investigation.
Thank you once again for an engaging discussion. Warm regards,
Nathan Manning
References:
1 Rouchaud A, Ramana C, Brinjikji W, et al. Wall Apposition Is a Key Factor for Aneurysm Occlusion after Flow Diversion: A Histologic Evaluation in 41 Rabbits. Am J Neuroradiol 2016;37:2087–91. doi:10.3174/ajnr.a4848
2 Warlo EM, Arnesen H, Seljeflot I. A brief review on resistance to P2Y12 receptor antagonism in coronary artery disease. Thrombosis J 2019;17:11. doi:10.1186/s12959-019-0197-5
3 Manning NW, Cheung A, Phillips TJ, et al. Pipeline shield with single antiplatelet therapy in aneurysmal subarachnoid haemorrhage: multicentre experience. Journal of neurointerventional surgery 2019;11:694–8. doi:10.1136/neurintsurg-2018-014363
4 Pierot L, Cognard C, Anxionnat R, et al. Ruptured intracranial aneurysms: factors affecting the rate and outcome of endovascular treatment complications in a series of 782 patients (CLARITY study). Radiology 2010;256:916–23. doi:10.1148/radiol.10092209
5 Kallmes DF, Brinjikji W, Boccardi E, et al. Aneurysm Study of Pipeline in an Observational Registry (ASPIRe). Interventional Neurology 2016;5:89–99. doi:10.1159/000446503
6 Kallmes D, Hanel R, Lopes D, et al. International retrospective study of the pipeline embolization device: a multicenter aneurysm treatment study. American Journal of Neuroradiology 2015;36:108–15. doi:10.3174/ajnr.a4111
7 Ajadi E, Kabir S, Cook A, et al. Predictive value of platelet reactivity unit (PRU) value for thrombotic and hemorrhagic events during flow diversion procedures: a meta-analysis. J Neurointerv Surg 2019;11:1123. doi:10.1136/neurintsurg-2019-014765
8 Hudson JS, Prout BS, Nagahama Y, et al. External Ventricular Drain and Hemorrhage in Aneurysmal Subarachnoid Hemorrhage Patients on Dual Antiplatelet Therapy: A Retrospective Cohort Study. Neurosurgery Published Online First: 2018. doi:10.1093/neuros/nyy127
9 Cagnazzo F, di Carlo D, Cappucci M, et al. Acutely Ruptured Intracranial Aneurysms Treated with Flow-Diverter Stents: A Systematic Review and Meta-Analysis. American Journal of Neuroradiology 2018;39:1669–75. doi:10.3174/ajnr.a5730
10 ten Brinck MF, Jäger M, de Vries J, et al. Flow diversion treatment for acutely ruptured aneurysms. J Neurointerv Surg 2019;:neurintsurg-2019-015077. doi:10.1136/neurintsurg-2019-015077
11 Gresele P. Antiplatelet agents in clinical practice and their haemorrhagic risk. Blood Transfus Trasfusione Del Sangue 2013;11:349–56. doi:10.2450/2013.0248-12
12 KIRKBY N, LEADER P, CHAN M, et al. Antiplatelet effects of aspirin vary with level of P2Y12 receptor blockade supplied by either ticagrelor or prasugrel. J Thromb Haemost 2011;9:2103–5. doi:10.1111/j.1538-7836.2011.04453.x
13 Warner TD, Nylander S, Whatling C. Anti‐platelet therapy: cyclo‐oxygenase inhibition and the use of aspirin with particular regard to dual anti‐platelet therapy. Brit J Clin Pharmaco 2011;72:619–33. doi:10.1111/j.1365-2125.2011.03943.x
We read with interest the case series by Manning’s et al.[1] using a surface modified flow-diverter stent (Pipeline Flex with Shield Technology, Medtronic Neurovascular, Irvine, California, USA). In this retrospective series, 14 ruptured intracranial aneurysms have been treated in the acute phase after Sub-Arachnoid Hemorrhage (SAH) with the Pipeline shield device under a Single Anti-Platelet Therapy (SAPT). The article concluded the PED-Shield to be safe to use in the acute treatment of ruptured intracranial aneurysms with SAPT.
However, in this small series, the authors reported one case of total stent occlusion and two cases of platelet aggregation noted on the PED-Shield device requiring to switch from single to dual antiplatelet treatment. Considering those three patients, thrombotic complications have been observed in 21.4 % of cases (3/14) in the acute period. Furthermore, in two cases (14.3 %), the authors reported rebleeding of the culprit aneurysm leading to patient death, pointing out the fact that flow-diverter devices may not immediately prevent the risk of aneurysm rerupture.
Anti-thrombogenic coating might have an added value in case of very specific aneurysms cases requiring the placement of a stent in the acute phase after rupture. Those specific cases are mainly dissecting or blister aneurysms for which endovascular or even surgical approach are difficult and carry a high risk of morbi-mortality[2][3]. In case of endovascular treatment, rece...
We read with interest the case series by Manning’s et al.[1] using a surface modified flow-diverter stent (Pipeline Flex with Shield Technology, Medtronic Neurovascular, Irvine, California, USA). In this retrospective series, 14 ruptured intracranial aneurysms have been treated in the acute phase after Sub-Arachnoid Hemorrhage (SAH) with the Pipeline shield device under a Single Anti-Platelet Therapy (SAPT). The article concluded the PED-Shield to be safe to use in the acute treatment of ruptured intracranial aneurysms with SAPT.
However, in this small series, the authors reported one case of total stent occlusion and two cases of platelet aggregation noted on the PED-Shield device requiring to switch from single to dual antiplatelet treatment. Considering those three patients, thrombotic complications have been observed in 21.4 % of cases (3/14) in the acute period. Furthermore, in two cases (14.3 %), the authors reported rebleeding of the culprit aneurysm leading to patient death, pointing out the fact that flow-diverter devices may not immediately prevent the risk of aneurysm rerupture.
Anti-thrombogenic coating might have an added value in case of very specific aneurysms cases requiring the placement of a stent in the acute phase after rupture. Those specific cases are mainly dissecting or blister aneurysms for which endovascular or even surgical approach are difficult and carry a high risk of morbi-mortality[2][3]. In case of endovascular treatment, recent meta-analyses have demonstrated the superiority of reconstructive techniques with flow diverter against deconstructive techniques despite the need for dual antiplatelet treatment with standard flow-diverter[4]. However, those specific aneurysms represent a tiny minority of the endovascularly treated aneurysms. They account for only 0.3% to 1% of intracranial aneurysms and 0.9% to 6.5% of ruptured aneurysms[5–7]. Most of others ruptured aneurysms are suitable for surgical or endovascular treatments without any need for use of a stent in the acute phase. Also, in case of implantation of stent for unruptured aneurysms, the need for dual antiplatelet treatment does not carry a high ischemic risk[8] and new antiplatelet treatments such as ticagrelor or prasugrel [9–14] recently helped to reduce the occurrence of this complication.
Beyond the potential indication of using PED shield with SAPT for ruptured aneurysms, we assume that PED-shield might be used with a SAPT in the setting of unruptured aneurysms. We recently followed this strategy in the setting of a 47-year-old woman allergic to aspirin with a medical history of severe angioedema and harboring an unruptured 11 mm left ophthalmic aneurysm. This patient had been premedicated with ticagrelor (Brilique 90 mg twice a day) and a PED-shield had been implanted without any trouble with perfect wall apposition improved with intra-stent balloon angioplasty. As routinely performed in our center, an MRI has been performed 24 hours after the treatment showing a normal patency of the flow-diverter without any ischemic complication on the DWI sequence. The patient has been discharged home on day 3 but suffered on day 6 of transient right arm palsy and right eye ptosis. An MRI has been performed in emergency depicting minimal ischemic lesions in the right MCA territory with an acute thrombosis of the stent. This patient improved with no deficit thanks to efficient supply from the Willis polygon. However, this observation illustrates the risk of using SAPT in the setting of intracranial stent implantation for the treatment of aneurysms even with the PED-shield device which has been presumed to carry low thrombogenicity.
In light of this observation, we would recommend further randomized clinical trial in order to assess the security of using SAPT treatment with the PED-Shield flow-diverter device.
REFERENCES
1 Manning NW, Cheung A, Phillips TJ, et al. Pipeline shield with single antiplatelet therapy in aneurysmal subarachnoid haemorrhage: multicentre experience. Journal of NeuroInterventional Surgery 2019;11:694–8. doi:10.1136/neurintsurg-2018-014363
2 Gonzalez AM, Narata AP, Yilmaz H, et al. Blood blister-like aneurysms: Single center experience and systematic literature review. European Journal of Radiology 2014;83:197–205. doi:10.1016/j.ejrad.2013.09.017
3 Kaschner MG, Kraus B, Petridis A, et al. Endovascular treatment of intracranial ‘blister’ and dissecting aneurysms. The Neuroradiology Journal 2019;32:353–65. doi:10.1177/1971400919861406
4 Rouchaud A, Brinjikji W, Cloft HJ, et al. Endovascular Treatment of Ruptured Blister-Like Aneurysms: A Systematic Review and Meta-Analysis with Focus on Deconstructive versus Reconstructive and Flow-Diverter Treatments. American Journal of Neuroradiology 2015;36:2331–9. doi:10.3174/ajnr.A4438
5 Nakagawa F, Kobayashi S, Takemae T, et al. Aneurysms protruding from the dorsal wall of the internal carotid artery. Journal of Neurosurgery 1986;65:303–8. doi:10.3171/jns.1986.65.3.0303
6 McLaughlin N, Laroche M, Bojanowski MW. Blister-like aneurysms of the internal carotid artery – management considerations. Neurochirurgie 2012;58:170–7. doi:10.1016/j.neuchi.2012.02.025
7 Abe M, Tabuchi K, Yokoyama H, et al. Blood blisterlike aneurysms of the internal carotid artery. Journal of Neurosurgery 1998;89:419–24. doi:10.3171/jns.1998.89.3.0419
8 Pikis S, Mantziaris G, Mamalis V, et al. Diffusion weighted image documented cerebral ischemia in the postprocedural period following pipeline embolization device with shield technology treatment of unruptured intracranial aneurysms: a prospective, single center study. Journal of NeuroInterventional Surgery 2019;:neurintsurg-2019-015363. doi:10.1136/neurintsurg-2019-015363
9 Atallah E, Saad H, Bekelis K, et al. The use of alternatives to clopidogrel in flow-diversion treatment with the Pipeline embolization device. Journal of Neurosurgery 2018;129:1130–5. doi:10.3171/2017.5.JNS162663
10 Moore JM, Adeeb N, Shallwani H, et al. A Multicenter Cohort Comparison Study of the Safety, Efficacy, and Cost of Ticagrelor Compared to Clopidogrel in Aneurysm Flow Diverter Procedures. Neurosurgery Published Online First: 5 May 2017. doi:10.1093/neuros/nyx079
11 Choi HH, Lee JJ, Cho YD, et al. Antiplatelet Premedication for Stent-Assisted Coil Embolization of Intracranial Aneurysms: Low-Dose Prasugrel vs Clopidogrel. Neurosurgery 2018;83:981–8. doi:10.1093/neuros/nyx591
12 Soize S, Foussier C, Manceau P-F, et al. Comparison of two preventive dual antiplatelet regimens for unruptured intracranial aneurysm embolization with flow diverter/disrupter: A matched-cohort study comparing clopidogrel with ticagrelor. Journal of Neuroradiology Published Online First: February 2019. doi:10.1016/j.neurad.2019.01.094
13 Barra ME, Berger K, Tesoro EP, et al. Periprocedural Neuroendovascular Antiplatelet Strategies for Thrombosis Prevention in Clopidogrel‐Hyporesponsive Patients. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 2019;39:317–34. doi:10.1002/phar.2228
14 Dmytriw AA, Phan K, Salem MM, et al. The Pipeline Embolization Device: Changes in Practice and Reduction of Complications in the Treatment of Anterior Circulation Aneurysms in a Multicenter Cohort. Neurosurgery Published Online First: 12 March 2019. doi:10.1093/neuros/nyz059
Dear Editor,
I read with interest the paper by Pierot et al [1]. They conducted a prospective study to examine factors of delayed thromboembolic events in 335 patients after coiling of unruptured intracranial aneurysms. The number of delayed TEEs was 8. The adjusted odds ratios (95% confidence intervals) of autosomal dominant polycystic kidney disease and post-procedure aneurysm remnant at procedure completion for delayed TEEs were 27.3 (3.9 to 190.2) and 9.9 (1.0 to 51.3), respectively. They understand the lack of statistical power in the multivariate analysis and did not intend to examine the causal association. I present a comment regarding the number of events in logistic regression analysis.
The limitation in the total number of events for logistic regression analysis was simulated to improve statistical power [2]. In addition, Peduzzi et al. evaluated the effect of the number of events per variable (EPV) on the outcome in logistic regression analysis [3], concluding that the number of EPV less than 10 has some problems for the prediction of dependent variable. There is an opinion that EPV value less than 10 is also acceptable to evaluate the association by logistic regression analysis [4]. Pierot et al. observed 8 events, which was not appropriate for multivariate analysis even for examining the association instead of prediction in a prospective study. I think that wide ranges of 95% confidence intervals may reflect unstable estimates in a logistic regr...
Show MoreDear Editor,
We have read with great interest the article entitled “Efficacy and mid-term outcome of middle meningeal artery embolization with or without burr hole evacuation for chronic subdural hematoma compared with burr hole evacuation alone” by Onyinzo, C., et al, published in Journal of NeuroInterventional Surgery (2021).
The article has compared the Surgical and Endovascular management of (CSDH) in the elderly population who are at high risk to developing (CSDH) due to their co-morbidities and the use of anti-thrombotic agents.
Show MoreIt is noted that the anti-thrombotic agents were stopped to both management arms. Upfront Middle meningeal artery embolization without stopping the anti-thrombotics, might be a strategy to mitigate the risk of cardio-embolic events.
In regards to the evaluation of the patients outcome, clinical parameters did not include motor assessment, which is a significant factor to favor a rapid surgical evacuation in these delicate patients.
As to the radiological follow up, cured (CSDH) were defined in the article with a thickness less than 10 mm. This is debatable as there are a lot of variations exists for this population in regards to brain volume and brain elasticity.
Finally, we would like to point out the timing of the follow up was not defines for all patients. This need to be harmonized better to a well-defined follow up timeline. Joyce, MD, et al,2 a suggested a time frame of 6 weeks after the treatment...
We read with great interest the recent paper by Vargas, et al. describing a novel beveled tip aspiration catheter with improved recanalization and patient outcome compared to conventional non-beveled tip catheters in a single-center retrospective study.[1] We want to express our sincere congratulations to the authors on this finding but also want to respectively present our disagreement on the mechanisms explaining the improved performance of the beveled tip catheter as compared to standard catheters.
The authors conclude that a primary reason for higher rate of complete clot ingestion for the beveled tip catheter relates to the area of the catheter tip. It is widely accepted that ingestion force predicts recanalization efficacy, and this force is proportional to tip area (A) and pressure drop (P). The authors note that the beveled tip leads to an ovalized tip area with a total tip area that is approximately 15% larger than a catheter with an equivalent inner diameter but standard non-beveled tip. They then propose that this 15% increase in tip area leads to a corresponding increase of ingestion force, using the standard F=A*P equation. However, this proposition is flawed. While it is true the total force is larger for the beveled tip catheter than a standard catheter, this total force includes two separate force components that are orthogonal to each other, including the ingestion force component (along the catheter’s length) that corks or ingests the clot and...
Show MoreWe congratulate Drs. Srivatsan and colleagues on their paper examining the effects of endovascular coiling of unruptured intracranial aneurysms (UIAs) on cognition using the Montreal Cognitive Assessment (MoCA).1 In particular, we appreciate the efforts made to sample the patients at multiple time points including pre-intervention and at 1-month and 6-months post-intervention. The study found that coiling did not diminish neurocognitive function per the MoCA, with there also being no correlation between follow-up MoCA scores and imaging findings, the overall results being comparable to the authors’ previous paper on MoCA scores following flow diversion for UIAs.2 Intriguingly, the MoCA scores at baseline were on average below the typical cut-off of 26 points, especially given the relatively young population (mean age 55.5 years).
However, as acknowledged by the authors, the ability of the study to discern post-coiling imaging changes was limited by both the small subset of the population that received follow-up imaging (17 of 33 patients, 51.5%) and the smaller subset that underwent MRI (9 patients, 27.3%).1 Diffusion-weighted imaging (DWI) sequences of MRI are most sensitive to identifying post-procedural ischemic injury following neuro-interventional procedures like coiling.3 DWI lesions occur quite frequently; for example, in the ENACT trial (Evaluating Neuroprotection in Aneurysm Coiling Therapy), 68% of patients had new lesions post-procedure, with an average o...
Show MoreAfter reading the interesting article by Jeon et al, indeed, the first series of cases of revascularization in cerebral infarction, it is important to point out several aspects related to the cancer patient. Cancer is a heterogeneous group of diseases with some points in common related to cellular behavior in the face of cell division controls and their local and systemic effects. Its incidence and prevalence are increasing, and the borders of treatment are changing, as is the disease itself. Patients with active cancer, therefore, should be approached in a multidisciplinary strategy, for the management of their oncological pathology or associated patient comorbidities. Stroke does not escape this strategy, because it does not have the same clinical impact to treat a patient with an oncological disease in early staging compared to one in advanced staging or in disease progression in palliative care and short calculated survival. It is not possible to establish a general rule of treatment in stroke with active cancer for these reasons, and a careful analysis of which primary tumors, their staging or clinical evolution of response to treatment, are necessary to clarify the clinical picture of stroke treatment in the oncological disease context.
Dear Editor,
Kaminsky et al1 present an interesting study regarding the logistics of patients eligible for endovascular stroke therapy (EVT). They conclude that whether patients with large vessel occlusion (LVO) are first admitted to a hospital with or without this treatment does not affect patient outcome.
Show MoreHowever, there are some difficulties interpreting the main statistical multivariate analyses. Firstly, although there is a clear presentation of how the main multivariate logistic regression analysis is performed, the covariates included in the model are not presented, and the model is not shown in any table. Secondly, the authors have included variables solely based on the strength of their association with the outcome, and not based on the potential of the variable to confound the relationship between the variable of interest (which center the patient is admitted to first), and the outcome. In this setting, it is our opinion that selecting covariates based on an etiological model, that focuses on the variable of interest, and includes covariates based on the potential for confounding, would be the best strategy.2 We disagree with the authors` choice of a prognostic model.
We urge the authors to provide a table showing the main analysis, or even repeat the main analysis using an etiological approach to model building and variable selection.
Despite these shortcomings, we commend the authors for undertaking such a relevant clinical study, and we...
Dear Editor:
We read with great joy the recent article by Kuhn et al entitled, “ Distal radial access in the anatomical snuffbox for neurointerventions: a feasibility, safety, and proof-of-concept study.” The authors should be congratulated on their work, as well as the use and maturation of the distal radial technique from diagnostic to interventional procedures. The authors detail their use of the Prelude sheaths which we agree are excellent low profile large lumen sheaths for radial access. We typically utilize the Glide Slender sheaths (Terumo) but both are excellent options. We also agree that the distal radial approach can be used for numerous interventions with access sizes from 4 to 6F, including 6F sheathless long 088 guides. Our choice for distal radial sheathless long 088 guides is Infinity LS (Stryker), and for 071 guides the Benchmark (penumbra) via a 6F sheath.
The authors noted their series was the first series to cover numerous neurointerventions with distal transradial access, however we would like to respectfully point out that we published on this topic in January of 2019 (accepted in March of 2019). Our paper by Rajah et al entitled, “ Snuff box radial access: A technical note on distal radial access for neuroendovascular procedures” can be found in Brain Circulation at the following citation available in PUBMED.
Rajah G, Garling RJ, Hudson M, Luqman A. Snuff box radial access: A technical note on distal radial access for neuroe...
Show MoreHaussen et al described a technique of blind exchange with mini-pinning technique (BEMP) for distal occlusion thrombectomy. The authors are to be commended for a well-written article show-casing an important technique for reperfusing distal occlusions in eloquent territories. We recently used a variation of this technique for mechanical thrombectomy in a large proximal vessel occlusion to great effect.
A 64-year-old man with atrial fibrillation presented to our institution with a right ICA terminus occlusion and NIHSS 17. Mechnical thrombectomy with a Solitaire retriever and 6F aspiration catheter (Solumbra technique) was attempted, but could not be performed due to marked tortuosity of the aortic arch and right cervical ICA, which prevented the aspiration catheter from reaching the clot. Two passes were attempted with the stentriever alone, without success (TICI 0). Therefore, a Trevo stentriever was advanced through the right ICA occlusion via a Markman microcatheter, the microcatheter was removed, and a 3MAX aspiration catheter was advanced over the retriever delivery wire. The stent was left in place for 5 minutes, and the thrombus was retrieved under continuous aspiration after partial ingestion/corking of the thrombus into the 3MAX aspiration catheter (BEMP). This was performed for a total of 2 passes, at the end of which there was complete revascularization of the right MCA territory (TICI 3).
The BEMP technique described by Haussen et al is an import...
Show MoreWe thank the respondents for providing their case experience and allowing further discussion of this important topic. We would first like to draw attention to specific points in the described case, before discussing some of the more general issues raised.
The respondents report one of many scenarios in which it may be undesirable to use dual antiplatelet therapy in the elective treatment of intracranial aneurysms with flow diverters. In this case, a 47-year-old woman with an 11 mm left ophthalmic aneurysm harbours a significant aspirin allergy. A single Pipeline Shield device under cover of ticagrelor was used to treat the aneurysm. The patient was well at discharge on postoperative day three but then developed symptomatic stent thrombosis on day 6. We draw attention to three points:
1) The respondents state that the stent achieved “perfect wall apposition improved with intra-stent balloon angioplasty.” Setting aside the impossibility of improving “perfect wall apposition” with angioplasty, this does allude to the increasingly understood importance of flow diverter wall apposition. [1] However, digital subtraction angiography assess stent apposition poorly. [1] The use of angioplasty suggests that there may have been some initial concern. Moreover, angioplasty itself may contribute to thrombosis if it promotes activation of the extrinsic clotting pathway by disrupting the endothelial layer. The phosphocholine “Shield” layer reduces thrombosis and platelet...
Show MoreWe read with interest the case series by Manning’s et al.[1] using a surface modified flow-diverter stent (Pipeline Flex with Shield Technology, Medtronic Neurovascular, Irvine, California, USA). In this retrospective series, 14 ruptured intracranial aneurysms have been treated in the acute phase after Sub-Arachnoid Hemorrhage (SAH) with the Pipeline shield device under a Single Anti-Platelet Therapy (SAPT). The article concluded the PED-Shield to be safe to use in the acute treatment of ruptured intracranial aneurysms with SAPT.
However, in this small series, the authors reported one case of total stent occlusion and two cases of platelet aggregation noted on the PED-Shield device requiring to switch from single to dual antiplatelet treatment. Considering those three patients, thrombotic complications have been observed in 21.4 % of cases (3/14) in the acute period. Furthermore, in two cases (14.3 %), the authors reported rebleeding of the culprit aneurysm leading to patient death, pointing out the fact that flow-diverter devices may not immediately prevent the risk of aneurysm rerupture.
Anti-thrombogenic coating might have an added value in case of very specific aneurysms cases requiring the placement of a stent in the acute phase after rupture. Those specific cases are mainly dissecting or blister aneurysms for which endovascular or even surgical approach are difficult and carry a high risk of morbi-mortality[2][3]. In case of endovascular treatment, rece...
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