PT - JOURNAL ARTICLE AU - D Fiorella AU - T N Turan AU - C P Derdeyn AU - M I Chimowitz TI - Current status of the management of symptomatic intracranial atherosclerotic disease: the rationale for a randomized trial of medical therapy and intracranial stenting AID - 10.1136/jnis.2009.000125 DP - 2009 Jul 01 TA - Journal of NeuroInterventional Surgery PG - 35--39 VI - 1 IP - 1 4099 - http://jnis.bmj.com/content/1/1/35.short 4100 - http://jnis.bmj.com/content/1/1/35.full SO - J NeuroIntervent Surg2009 Jul 01; 1 AB - Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) is a randomized trial comparing aggressive medical management alone with aggressive medical management in combination with angioplasty and stenting using the Gateway–Wingspan system in patients with symptomatic, high-grade, intracranial stenosis. This trial represents a landmark in the maturation of the field of neurointervention, establishing a foundation for evidenced-based practice. We review the natural history of symptomatic intracranial stenosis when treated medically, the available interventional therapies and the rationale for the design of the SAMMPRIS trial.