PT - JOURNAL ARTICLE AU - Albert J Yoo AU - Don Frei AU - Satoshi Tateshima AU - Aquilla S Turk AU - Ferdinand K Hui AU - Allan L Brook AU - Don V Heck AU - Joshua A Hirsch TI - The Penumbra Stroke System: a technical review AID - 10.1136/neurintsurg-2011-010080 DP - 2012 May 01 TA - Journal of NeuroInterventional Surgery PG - 199--205 VI - 4 IP - 3 4099 - http://jnis.bmj.com/content/4/3/199.short 4100 - http://jnis.bmj.com/content/4/3/199.full SO - J NeuroIntervent Surg2012 May 01; 4 AB - Major ischemic strokes secondary to proximal artery occlusions are responsible for significant morbidity and mortality. Owing to extensive clot burden, these strokes are poorly responsive to intravenous tissue plasminogen activator. The introduction of endovascular therapy, particularly mechanical devices, has resulted in markedly improved recanalization rates of large vessel occlusions. With increasing experience with the Penumbra Stroke System and the 054 reperfusion catheter, there has been further improvement in TIMI 2 and 3 revascularization rates with faster times to vessel opening. The aim of this technical review is to convey various tips and tricks learnt from this experience.