RT Journal Article SR Electronic T1 The Penumbra Stroke System: a technical review JF Journal of NeuroInterventional Surgery JO J NeuroIntervent Surg FD BMJ Publishing Group Ltd. SP 199 OP 205 DO 10.1136/neurintsurg-2011-010080 VO 4 IS 3 A1 Albert J Yoo A1 Don Frei A1 Satoshi Tateshima A1 Aquilla S Turk A1 Ferdinand K Hui A1 Allan L Brook A1 Don V Heck A1 Joshua A Hirsch YR 2012 UL http://jnis.bmj.com/content/4/3/199.abstract AB Major ischemic strokes secondary to proximal artery occlusions are responsible for significant morbidity and mortality. Owing to extensive clot burden, these strokes are poorly responsive to intravenous tissue plasminogen activator. The introduction of endovascular therapy, particularly mechanical devices, has resulted in markedly improved recanalization rates of large vessel occlusions. With increasing experience with the Penumbra Stroke System and the 054 reperfusion catheter, there has been further improvement in TIMI 2 and 3 revascularization rates with faster times to vessel opening. The aim of this technical review is to convey various tips and tricks learnt from this experience.