RT Journal Article SR Electronic T1 Aneurysm permeability following coil embolization: packing density and coil distribution JF Journal of NeuroInterventional Surgery JO J NeuroIntervent Surg FD BMJ Publishing Group Ltd. SP 676 OP 681 DO 10.1136/neurintsurg-2014-011289 VO 7 IS 9 A1 Ju-Yu Chueh A1 Srinivasan Vedantham A1 Ajay K Wakhloo A1 Sarena L Carniato A1 Ajit S Puri A1 Conrad Bzura A1 Spencer Coffin A1 Alexei A Bogdanov, Jr A1 Matthew J Gounis YR 2015 UL http://jnis.bmj.com/content/7/9/676.abstract AB Background Rates of durable aneurysm occlusion following coil embolization vary widely, and a better understanding of coil mass mechanics is desired. The goal of this study is to evaluate the impact of packing density and coil uniformity on aneurysm permeability.Methods Aneurysm models were coiled using either Guglielmi detachable coils or Target coils. The permeability was assessed by taking the ratio of microspheres passing through the coil mass to those in the working fluid. Aneurysms containing coil masses were sectioned for image analysis to determine surface area fraction and coil uniformity.Results All aneurysms were coiled to a packing density of at least 27%. Packing density, surface area fraction of the dome and neck, and uniformity of the dome were significantly correlated (p<0.05). Hence, multivariate principal components-based partial least squares regression models were used to predict permeability. Similar loading vectors were obtained for packing and uniformity measures. Coil mass permeability was modeled better with the inclusion of packing and uniformity measures of the dome (r2=0.73) than with packing density alone (r2=0.45). The analysis indicates the importance of including a uniformity measure for coil distribution in the dome along with packing measures.Conclusions A densely packed aneurysm with a high degree of coil mass uniformity will reduce permeability.